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CERID Bibliography
Crystal structures of Plasmodium falciparum cytosolic tryptophanyl-tRNA synthetase and its potential as a target for structure-guided drug design. Mol Biochem Parasitol. 2013 ;189(1-2):26-32.
. Induced resistance to methionyl-tRNA synthetase inhibitors in Trypanosoma brucei is due to overexpression of the target. Antimicrob Agents Chemother. 2013 ;57(7):3021-8.
. Distinct states of methionyl-tRNA synthetase indicate inhibitor binding by conformational selection. Structure. 2012 ;20(10):1681-91.
Multiple determinants for selective inhibition of apicomplexan calcium-dependent protein kinase CDPK1. J Med Chem. 2012 ;55(6):2803-10.
Structure of the prolyl-tRNA synthetase from the eukaryotic pathogen Giardia lamblia. Acta Crystallogr D Biol Crystallogr. 2012 ;68(Pt 9):1194-200.
. Urea-based inhibitors of Trypanosoma brucei methionyl-tRNA synthetase: selectivity and in vivo characterization. J Med Chem. 2012 ;55(14):6342-51.
Crystal structures of three protozoan homologs of tryptophanyl-tRNA synthetase. Mol Biochem Parasitol. 2011 ;177(1):20-8.
The double-length tyrosyl-tRNA synthetase from the eukaryote Leishmania major forms an intrinsically asymmetric pseudo-dimer. J Mol Biol. 2011 ;409(2):159-76.
Screening a fragment cocktail library using ultrafiltration. Anal Bioanal Chem. 2011 ;401(5):1585-91.
Selective inhibitors of methionyl-tRNA synthetase have potent activity against Trypanosoma brucei Infection in Mice. Antimicrob Agents Chemother. 2011 ;55(5):1982-9.
Structure determination of glycogen synthase kinase-3 from Leishmania major and comparative inhibitor structure-activity relationships with Trypanosoma brucei GSK-3. Mol Biochem Parasitol. 2011 ;176(2):98-108.
. The crystal structure and activity of a putative trypanosomal nucleoside phosphorylase reveal it to be a homodimeric uridine phosphorylase. J Mol Biol. 2010 ;396(5):1244-59.
Crystal structure of the aspartyl-tRNA synthetase from Entamoeba histolytica. Mol Biochem Parasitol. 2010 ;169(2):95-100.
Crystal structures of trypanosomal histidyl-tRNA synthetase illuminate differences between eukaryotic and prokaryotic homologs. J Mol Biol. 2010 ;397(2):481-94.
Prediction of protein crystallization outcome using a hybrid method. J Struct Biol. 2010 ;171(1):64-73.
The structure of tryptophanyl-tRNA synthetase from Giardia lamblia reveals divergence from eukaryotic homologs. J Struct Biol. 2010 ;171(2):238-43.
. Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors. Nat Struct Mol Biol. 2010 ;17(5):602-7.
Use of thermal melt curves to assess the quality of enzyme preparations. Anal Biochem. 2010 ;399(2):268-75.
Buffer optimization of thermal melt assays of Plasmodium proteins for detection of small-molecule ligands. J Biomol Screen. 2009 ;14(6):700-7.
Fragment-based cocktail crystallography by the medical structural genomics of pathogenic protozoa consortium. Curr Top Med Chem. 2009 ;9(18):1678-87.
The role of medical structural genomics in discovering new drugs for infectious diseases. PLoS Comput Biol. 2009 ;5(10):e1000530.
. Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies. Mol Microbiol. 2008 ;68(1):37-50.
Structural genomics of pathogenic protozoa: an overview. Methods Mol Biol. 2008 ;426:497-513.
Structure of a Trypanosoma brucei alpha/beta-hydrolase fold protein with unknown function. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 ;64(Pt 6):474-8.