We link multiple biomedical disciplines for research, training, and program development in the field of innate immunity.

IMPORTANT

SARS-CoV-2 and COVID-19

The CIIID is working with colleagues across the local, national, and global responses to SARS-CoV-2 infection and COVID-19 disease. Our member’s efforts include in-depth research and development activities to understand the virus-host interactions that regulate the innate and adaptive immune response to SARS-CoV-2 infection, to identify immune correlates of protection, build therapeutic antibodies, develop a novel vaccine against SARS-CoV-2, and identifying innate immune interventions to control COVID-19 disease.

For updates on local and global COVID-19 status, the following resources are available:

A new study led by Dr. Katharina Esser-Nobis reveals the intracellular molecular and biochemical interactions of RIG-I-like receptors (RLRs) during the process of innate immune activation directed by virus infection and double stranded RNA (dsRNA).

This research examined all three RLRs, RIG-I, MDA5, LGP2, to reveal their intracellular movement and localization during acute RNA virus infection and the cellular response to dsRNA, a prominent pathogen associated molecular pattern that triggers innate immune activation. LGP2 function and localization were found to be key in regulating RLR signaling and innate immune activation. This work has implications for strategies to target the RLR pathway for the control of innate immune actions in immune programming against infection and autoimmunity.    

CIIID links with other UW Centers and international sites to establish UWARN to identify and combat emerging viruses

NEWS RELEASE from UW Medicine Newsroom

UWARN map

A map of the international collaborating sites for UWARN, a viral pandemic research network

United World Antiviral Research Network (UWARN) forms

UWARN will be part of emerging pandemic virus surveillance; diagnostics, therapeutics and vaccine development; and immune response studies

Gale Lab, Dr. Caleb Stokes awarded NIAID Clinical Scientist Research Career Development K08 Award.

Caleb Stokes, MD, PhD has been awarded a K08 grant from NIH/NIAID to support the development of his independent research program defining the processes of innate immunity that control virus infection in the central nervous system. Focusing on Zika virus infection in human induced neural progenitor cells, his K08 award work aims to determine how innate immunity directs the outcome Zika virus infection in the developing brain.

New paper from the Gale Lab describing a study led by Dr. Alison Kell shows that Hantavirus triggers innate immune actions in part through RLR signaling to differentially control virus in models of reservoir versus non-reservoir hosts.

This research has implications for disease following zoonotic virus transmission, and importantly points to additional, non-RLR innate immune programs impacting innate immunity against Hantaviruses across hosts.  Link to paper: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1008483

 

Dr. Katherine Wuertz completes her dissertation and returns to the US Army as Major

Data Stories | Understanding STING

See how researcher Kathryn McGuckin Wuertz is trying to understand the relationship between infectious diseases and neurological diseases