We link multiple biomedical disciplines for research, training, and program development in the field of innate immunity.

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SARS-CoV-2 and COVID-19

The CIIID is working with colleagues across the local, national, and global responses to SARS-CoV-2 infection and COVID-19 disease. Our member’s efforts include in-depth research and development activities to understand the virus-host interactions that regulate the innate and adaptive immune response to SARS-CoV-2 infection, to identify immune correlates of protection, build therapeutic antibodies, develop a novel vaccine against SARS-CoV-2, and identifying innate immune interventions to control COVID-19 disease.

For updates on local and global COVID-19 status, the following resources are available:

How the Gale Lab “RIG”s innate immune responses against hepatitis B

From the Gale Lab, Pathogen Associated Malignancies Program, Cancer Consortium

Link to Fred Hutch article written by AE Spens

CIIID response to COVID-19 and the SARS-CoV-2 pandemic

CIIID investigators are collaborating with local and international colleagues in the response to the SARS-CoV-2 pandemic. These activities include directing the laboratory analysis to assess the efficacy of the Moderna vaccine across clinical trials in efforts that have now facilitated the US FDA and CDC approval of this vaccine for emergency use to vaccinate the American population and international populations.  

We have also:

A new study led by Dr. Katharina Esser-Nobis reveals the intracellular molecular and biochemical interactions of RIG-I-like receptors (RLRs) during the process of innate immune activation directed by virus infection and double stranded RNA (dsRNA).

This research examined all three RLRs, RIG-I, MDA5, LGP2, to reveal their intracellular movement and localization during acute RNA virus infection and the cellular response to dsRNA, a prominent pathogen associated molecular pattern that triggers innate immune activation. LGP2 function and localization were found to be key in regulating RLR signaling and innate immune activation. This work has implications for strategies to target the RLR pathway for the control of innate immune actions in immune programming against infection and autoimmunity.    

CIIID links with other UW Centers and international sites to establish UWARN to identify and combat emerging viruses

NEWS RELEASE from UW Medicine Newsroom


A map of the international collaborating sites for UWARN, a viral pandemic research network

United World Antiviral Research Network (UWARN) forms

UWARN will be part of emerging pandemic virus surveillance; diagnostics, therapeutics and vaccine development; and immune response studies

Gale Lab, Dr. Caleb Stokes awarded NIAID Clinical Scientist Research Career Development K08 Award.

Caleb Stokes, MD, PhD has been awarded a K08 grant from NIH/NIAID to support the development of his independent research program defining the processes of innate immunity that control virus infection in the central nervous system. Focusing on Zika virus infection in human induced neural progenitor cells, his K08 award work aims to determine how innate immunity directs the outcome Zika virus infection in the developing brain.