We link multiple biomedical disciplines for research, training, and program development in the field of innate immunity.

Upcoming Events

CIIID Summer Quarter Seminar: Nicolas Manel

Event Date: 
Wednesday, August 14, 2019 - 10:00am

PresenterNicolas Manel, Ph.D., INSERM Director of Research, Institut Curie

Talk Title"Activation of innate immune sensors by viruses and self: DNA's identity crisis?"

"The ability of cells to distinguish self from non-self (such as viruses) is universal in life. In animals, cells rely on innate sensors to detect viruses and launch immune responses. The biology of these sensors is well established at cellular membranes and in the cytosol. However, many viruses must enter the nucleus to replicate, suggesting the existence of nuclear innate immune sensors. In this talk, I will present our recent advances on this topic using HIV and self DNA as models."

Event flyer

Publications

Interleukin-1β Induces mtDNA Release to Activate Innate Immune Signaling via cGAS-STING.

Author: 
Michael Gale Jr., Ph.D.
Publisher: 
Mol Cell
Published: 
Mar 2019

Interferon lambda 4 expression is suppressed by the host during viral infection

Author: 
Ram Savan, Ph.D.
Publisher: 
J Exp Med. 2016 Oct 31. pii: jem.20160437
Published: 
Oct 2016

Affiliate Core

Seattle Genomics

(SG) is a service core at the University of Washington that provides custom sequencing and data analysis solutions. SG maintains multiple instruments including two next generation Illumina sequencers (NextSeq 500 and Miseq), an Agilent Microarray Feature extractor system,  a Beckman FX automation workstation, robotics liquid handling systems for high throughput, and extensive bioinformatics services.

SG is a component of the Washington National Primate Research Center and is operated by the Division of NHP Systems Biology in the laboratory of Michael Gale, Jr.  For additional information about Seattle Genomics and their services, visit their website at https://www.seattlegenomics.com/ or email info@seattlegenomics.com