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CERID Bibliography

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2013
Koh CY, Kim JE, Napoli AJ, Verlinde CLMJ, Fan E, Buckner FS, Van Voorhis WC, Hol WGJ. Crystal structures of Plasmodium falciparum cytosolic tryptophanyl-tRNA synthetase and its potential as a target for structure-guided drug design. Mol Biochem Parasitol. 2013 ;189(1-2):26-32.
Suryadevara PK, Racherla KK, Olepu S, Norcross NR, Tatipaka HB, Arif JA, Planer JD, Lepesheva GI, Verlinde CLMJ, Buckner FS, et al. Dialkylimidazole inhibitors of Trypanosoma cruzi sterol 14α-demethylase as anti-Chagas disease agents. Bioorg Med Chem Lett. 2013 ;23(23):6492-9.
Ranade RM, Gillespie RJ, Shibata S, Verlinde CLMJ, Fan E, Hol WGJ, Buckner FS. Induced resistance to methionyl-tRNA synthetase inhibitors in Trypanosoma brucei is due to overexpression of the target. Antimicrob Agents Chemother. 2013 ;57(7):3021-8.
Ojo KK, Eastman RT, Vidadala R, Zhang Z, Rivas KL, Choi R, Lutz JD, Reid MC, Fox AMW, Hulverson MA, et al. A specific inhibitor of PfCDPK4 blocks malaria transmission: Chemical-genetic validation. J Infect Dis. 2013 .
2012
Zhang Z, Ojo KK, Johnson SM, Larson ET, He P, Geiger JA, Castellanos-Gonzalez A, White CA, Parsons M, Merritt EA, et al. Benzoylbenzimidazole-based selective inhibitors targeting Cryptosporidium parvum and Toxoplasma gondii calcium-dependent protein kinase-1. Bioorg Med Chem Lett. 2012 ;22(16):5264-7.
Koh CY, Kim JE, Shibata S, Ranade RM, Yu M, Liu J, Gillespie RJ, Buckner FS, Verlinde CLMJ, Fan E, et al. Distinct states of methionyl-tRNA synthetase indicate inhibitor binding by conformational selection. Structure. 2012 ;20(10):1681-91.
Larson ET, Ojo KK, Murphy RC, Johnson SM, Zhang Z, Kim JE, Leibly DJ, Fox AMW, Reid MC, Dale EJ, et al. Multiple determinants for selective inhibition of apicomplexan calcium-dependent protein kinase CDPK1. J Med Chem. 2012 ;55(6):2803-10.
Buckner FS, Bahia MTerezinha, Suryadevara PK, White KL, Shackleford DM, Chennamaneni NKumar, Hulverson MA, Laydbak JU, Chatelain E, Scandale I, et al. Pharmacological characterization, structural studies, and in vivo activities of anti-Chagas disease lead compounds derived from tipifarnib. Antimicrob Agents Chemother. 2012 ;56(9):4914-21.
Larson ET, Kim JE, Napuli AJ, Verlinde CLMJ, Fan E, Zucker FH, Van Voorhis WC, Buckner FS, Hol WGJ, Merritt EA. Structure of the prolyl-tRNA synthetase from the eukaryotic pathogen Giardia lamblia. Acta Crystallogr D Biol Crystallogr. 2012 ;68(Pt 9):1194-200.
Ojo KK, Pfander C, Mueller NR, Burstroem C, Larson ET, Bryan CM, Fox AMW, Reid MC, Johnson SM, Murphy RC, et al. Transmission of malaria to mosquitoes blocked by bumped kinase inhibitors. J Clin Invest. 2012 ;122(6):2301-5.
Shibata S, Gillespie RJ, Ranade RM, Koh CY, Kim JE, Laydbak JU, Zucker FH, Hol WGJ, Verlinde CLMJ, Buckner FS, et al. Urea-based inhibitors of Trypanosoma brucei methionyl-tRNA synthetase: selectivity and in vivo characterization. J Med Chem. 2012 ;55(14):6342-51.
2011
Merritt EA, Arakaki TL, Gillespie R, Napuli AJ, Kim JE, Buckner FS, Van Voorhis WC, Verlinde CLMJ, Fan E, Zucker F, et al. Crystal structures of three protozoan homologs of tryptophanyl-tRNA synthetase. Mol Biochem Parasitol. 2011 ;177(1):20-8.
Larson ET, Kim JE, Castaneda LJ, Napuli AJ, Zhang Z, Fan E, Zucker FH, Verlinde CLMJ, Buckner FS, Van Voorhis WC, et al. The double-length tyrosyl-tRNA synthetase from the eukaryote Leishmania major forms an intrinsically asymmetric pseudo-dimer. J Mol Biol. 2011 ;409(2):159-76.
Shibata S, Zhang Z, Korotkov KV, Delarosa J, Napuli A, Kelley AM, Mueller N, Ross J, Zucker FH, Buckner FS, et al. Screening a fragment cocktail library using ultrafiltration. Anal Bioanal Chem. 2011 ;401(5):1585-91.
Shibata S, Gillespie RJ, Kelley AM, Napuli AJ, Zhang Z, Kovzun KV, Pefley RM, Lam J, Zucker FH, Van Voorhis WC, et al. Selective inhibitors of methionyl-tRNA synthetase have potent activity against Trypanosoma brucei Infection in Mice. Antimicrob Agents Chemother. 2011 ;55(5):1982-9.
Ojo KK, Arakaki TL, Napuli AJ, Inampudi KK, Keyloun KR, Zhang L, Hol WGJ, Verlinde CLMJ, Merritt EA, Van Voorhis WC. Structure determination of glycogen synthase kinase-3 from Leishmania major and comparative inhibitor structure-activity relationships with Trypanosoma brucei GSK-3. Mol Biochem Parasitol. 2011 ;176(2):98-108.
Larson ET, Kim JE, Zucker FH, Kelley A, Mueller N, Napuli AJ, Verlinde CLMJ, Fan E, Buckner FS, Van Voorhis WC, et al. Structure of Leishmania major methionyl-tRNA synthetase in complex with intermediate products methionyladenylate and pyrophosphate. Biochimie. 2011 ;93(3):570-82.
2010
Larson ET, Mudeppa DG, Gillespie RJ, Mueller N, Napuli AJ, Arif JA, Ross J, Arakaki TL, Lauricella A, Detitta G, et al. The crystal structure and activity of a putative trypanosomal nucleoside phosphorylase reveal it to be a homodimeric uridine phosphorylase. J Mol Biol. 2010 ;396(5):1244-59.
Merritt EA, Arakaki TL, Larson ET, Kelley A, Mueller N, Napuli AJ, Zhang L, Deditta G, Luft J, Verlinde CLMJ, et al. Crystal structure of the aspartyl-tRNA synthetase from Entamoeba histolytica. Mol Biochem Parasitol. 2010 ;169(2):95-100.
Merritt EA, Arakaki TL, Gillespie RJ, Larson ET, Kelley A, Mueller N, Napuli AJ, Kim J, Zhang L, Verlinde CLMJ, et al. Crystal structures of trypanosomal histidyl-tRNA synthetase illuminate differences between eukaryotic and prokaryotic homologs. J Mol Biol. 2010 ;397(2):481-94.
Murphy RC, Ojo KK, Larson ET, Castellanos-Gonzalez A, Perera GBK, Keyloun KR, Kim JE, Bhandari JG, Muller NR, Verlinde CLMJ, et al. Discovery of Potent and Selective Inhibitors of Calcium-Dependent Protein Kinase 1 (CDPK1) from C. parvum and T. gondii. ACS Med Chem Lett. 2010 ;1(7):331-335.
Zucker FH, Stewart C, Delarosa J, Kim J, Zhang L, Xiao L, Ross J, Napuli AJ, Mueller N, Castaneda LJ, et al. Prediction of protein crystallization outcome using a hybrid method. J Struct Biol. 2010 ;171(1):64-73.
Kraus JM, Tatipaka HBabu, McGuffin SA, Chennamaneni NKumar, Karimi M, Arif J, Verlinde CLMJ, Buckner FS, Gelb MH. Second generation analogues of the cancer drug clinical candidate tipifarnib for anti-Chagas disease drug discovery. J Med Chem. 2010 ;53(10):3887-98.
Arakaki TL, Carter M, Napuli AJ, Verlinde CLMJ, Fan E, Zucker F, Buckner FS, Van Voorhis WC, Hol WGJ, Merritt EA. The structure of tryptophanyl-tRNA synthetase from Giardia lamblia reveals divergence from eukaryotic homologs. J Struct Biol. 2010 ;171(2):238-43.
Ojo KK, Larson ET, Keyloun KR, Castaneda LJ, DeRocher AE, Inampudi KK, Kim JE, Arakaki TL, Murphy RC, Zhang L, et al. Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors. Nat Struct Mol Biol. 2010 ;17(5):602-7.

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