You are here
Structural genomics of pathogenic protozoa: an overview.
| Title | Structural genomics of pathogenic protozoa: an overview. |
| Publication Type | Journal Article |
| Year of Publication | 2008 |
| Authors | Fan, E, Baker, D, Fields, S, Gelb, MH, Buckner, FS, Van Voorhis, WC, Phizicky, E, Dumont, M, Mehlin, C, Grayhack, E, Sullivan, M, Verlinde, C, Detitta, G, Meldrum, DR, Merritt, EA, Earnest, T, Soltis, M, Zucker, F, Myler, PJ, Schoenfeld, L, Kim, D, Worthey, L, Lacount, D, Vignali, M, Li, J, Mondal, S, Massey, A, Carroll, B, Gulde, S, Luft, J, Desoto, L, Holl, M, Caruthers, J, Bosch, J, Robien, M, Arakaki, T, Holmes, M, Letrong, I, Hol, WGJ |
| Journal | Methods Mol Biol |
| Volume | 426 |
| Pagination | 497-513 |
| Date Published | 2008 |
| ISSN | 1064-3745 |
| Keywords | Animals, Crystallization, Crystallography, X-Ray, Genomics, Plasmodium, Protozoan Proteins, Trypanosomatina |
| Abstract | The Structural Genomics of Pathogenic Protozoa (SGPP) Consortium aimed to determine crystal structures of proteins from trypanosomatid and malaria parasites in a high throughput manner. The pipeline of target selection, protein production, crystallization, and structure determination, is sketched. Special emphasis is given to a number of technology developments including domain prediction, the use of "co-crystallants," and capillary crystallization. "Fragment cocktail crystallography" for medical structural genomics is also described. |
| DOI | 10.1007/978-1-60327-058-8_33 |
| Alternate Journal | Methods Mol. Biol. |
| PubMed ID | 18542886 |
