We link multiple biomedical disciplines for research, training, and program development in the field of innate immunity.

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COVID PUBLICATIONS

Publications

Human DNA-PK activates a STING-independent DNA sensing pathway.
The Plasticity of Newly Formed B Cells.
RNA-binding protein isoforms ZAP-S and ZAP-L have distinct antiviral and immune resolution functions.
Immune Evasion Strategies Used by Zika Virus to Infect the Fetal Eye and Brain.
Macrophage-associated wound healing contributes to African green monkey SIV pathogenesis control.
Reprogramming the adjuvant properties of aluminum oxyhydroxide with nanoparticle technology.

AFFILIATE CORE

IMPORTANT

SARS-CoV-2 and COVID-19

The CIIID is working with colleagues across the local, national, and global responses to SARS-CoV-2 infection and COVID-19 disease. Our member’s efforts include in-depth research and development activities to understand the virus-host interactions that regulate the innate and adaptive immune response to SARS-CoV-2 infection, to identify immune correlates of protection, build therapeutic antibodies, develop a novel vaccine against SARS-CoV-2, and identifying innate immune interventions to control COVID-19 disease.

For updates on local and global COVID-19 status, the following resources are available:

RACING to HALT the Zika virus in its spread aROUND the world

Immunologist Michael Gale Jr., ’8 5, ’94, and his team of scientists and students are focusing on a drug-like molecule that triggers a body's innate immunity to fight infection in a range of global pathogens including Zika, hepatitis C and West Nile.

Full Article:  "Zeroing in on Zika" was featured in the UW Columns Magazine in the December 2016 Issue.   View in printable PDF, click here 

Hepatitis C tricks liver cells to sabotage immune defenses

Virus induces liver cells to make molecules that inhibit production of a key immune signaling receptor

By Michael McCarthy  |  HSNewsBeat  |  Updated 12:00 PM, 11.14.2016

Link to NewsBeat article

Study details how Zika damages fetal brain

For the first time, abnormal brain development following a Zika infection during pregnancy has been documented experimentally in the offspring of a non-human primate.  

The researchers’ observations of how Zika virus arrested fetal brain formation in a pigtail macaque could provide a model for testing therapeutic interventions. 

The findings are reported Sept. 12 in Nature Medicine. Read the scientific paper.  

As Zika rages, Seattle scientists step up antiviral drug research

Michael Gale

Scientists at the University of Washington and Kineta in Seattle have acquired samples of the Zika virus now exploding in more than 25 countries to conduct tests that could lead to antiviral compounds that can stop that bug — and other global pathogens.

University of Washington immunologist Michael Gale Jr. holds frozen isolates from the Zika virus outbreak in Brazil that he will use in his testing. (Steve Ringman/The Seattle Times)

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