We link multiple biomedical disciplines for research, training, and program development in the field of innate immunity.

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COVID PUBLICATIONS

Publications

Human DNA-PK activates a STING-independent DNA sensing pathway.
The Plasticity of Newly Formed B Cells.
RNA-binding protein isoforms ZAP-S and ZAP-L have distinct antiviral and immune resolution functions.
Immune Evasion Strategies Used by Zika Virus to Infect the Fetal Eye and Brain.
Macrophage-associated wound healing contributes to African green monkey SIV pathogenesis control.
Reprogramming the adjuvant properties of aluminum oxyhydroxide with nanoparticle technology.

AFFILIATE CORE

IMPORTANT

SARS-CoV-2 and COVID-19

The CIIID is working with colleagues across the local, national, and global responses to SARS-CoV-2 infection and COVID-19 disease. Our member’s efforts include in-depth research and development activities to understand the virus-host interactions that regulate the innate and adaptive immune response to SARS-CoV-2 infection, to identify immune correlates of protection, build therapeutic antibodies, develop a novel vaccine against SARS-CoV-2, and identifying innate immune interventions to control COVID-19 disease.

For updates on local and global COVID-19 status, the following resources are available:

CIIID Awarded New Grant from the Seattle Foundation

CIIID Awarded New Grant from the Seattle Foundation

Compound found to trigger innate immunity against viruses

RIG-I

http://hsnewsbeat.washington.edu/story/compound-found-trigger-innate-immunity-against-viruses

Success at inducing gene action to suppress Ebola, West Nile and other RNA viruses

By Bobbi Nodell  |  HSNewsBeat  |  Updated 12:15 PM, 12.16.2015

CIIID Investigators in the News: New Immune-based Therapeutics to Treat Lupus Autoimmune Disease

CIIID Investigator Dr. Keith Elkon is leading the way in developing new immune-based therapeutics to treat autoimmune diseases such as systemic lupus erythematosus (SLE).  A Professor of Medicine and Adjunct Professor in the Department of Immunology at the University of Washington, Dr. Elkon utilized findings in his laboratory that linked autoantibodies and immune complexes to inflammation that arises from innate immune cells.  Dr. Elkon and Dr. Jeff Ledbetter, a Professor in Rheumatology at the University of Washington, partnered with entrepreneur Dr.

CIIID-Solid Organ Transplant Infectious Disease Program Form Partnership to Provide CIIID Researchers with Access to Human Specimens

The CIIID announced today the establishment of a formal partnership with the University of Washington Solid Organ Transplant Infectious Disease Program to provide access to human specimens (tissue, cells, blood) for use in innate immune studies.  Much of the groundbreaking work in innate immunity is accomplished by studying immune processes in the well-controlled mouse models of relevant human disease; however, observations from the mouse model must be validated in human cells and tissues to verify their clinical relevance to people.

Inaugural CIIID Symposium: Innate Immunity in Health and Disease

On July 18 - 19, 2016 CIIID hosted a 2-day scientific symposium consisting of 7 sessions with featured speakers focusing on innate immunity and immune disease.