Keystone Symposia in Taiwan
Innate Immune Receptors:  Roles in Immunology and Beyond

Taipei, Taiwan | March 10–14, 2019
Humanities/Social Sciences Building of Academia Sinica

Scientific Organizers:
Jenny P.Y. Ting, University of North Carolina at Chapel Hill, USA
Shie-Liang Edmond Hsieh, Academia Sinica, Taiwan
Fu-Tong Liu, Institute of Biomedical Sciences, Academia Sinica, Taiwan
Michael Gale, Jr., University of Washington, USA
Siamon Gordon, University of Oxford, UK

Organized in collaboration with Academia Sinica
The importance of innate immune receptors was first appreciated in infectious diseases and autoinflammatory disorders. However, it is now clear that their roles extend beyond innate immunology. The crucial roles of these receptors in many clinically relevant fields and their newly documented role in non-immune cells underscore their importance in biologic processes and diseases such as cancer cell death and signaling, DNA damage, stress response, stem cell proliferation/differentiation, vaccine adjuvanticity, age-related dementia, metabolic disorders and microbiome balance. This conference will bring together an interdisciplinary group of investigators to explore the broad and important role of innate immune receptors.

Plenary Session Topics:
• Innate Immune Receptors and Nucleic Acid Sensing
• Innate Immune Receptors in Cell Death and Proliferation
• Innate Immune Receptors and Diseases
• Innate Immunity and Therapeutics
• Innate Immune Receptors in Viral Infection
• Innate Immunity in Bacterial Infection
• Innate Immunity and Diseases
• Innate Immune Receptors and the Microbiome

Scholarship/Discounted Abstract Deadlne: Nov 13, 2018; Abstract Deadline (for short talks): Dec 11, 2018;
Discounted Registration Deadline: Jan 17, 2019
Visit www.keystonesymposia.org/19M1 for more details.

Presenter:  Nicolas Manel, Ph.D., INSERM Director of Research, Institut Curie

Talk Title:  "Activation of innate immune sensors by viruses and self: DNA's identity crisis?"

"The ability of cells to distinguish self from non-self (such as viruses) is universal in life. In animals, cells rely on innate sensors to detect viruses and launch immune responses. The biology of these sensors is well established at cellular membranes and in the cytosol. However, many viruses must enter the nucleus to replicate, suggesting the existence of nuclear innate immune sensors. In this talk, I will present our recent advances on this topic using HIV and self DNA as models."

Event flyer