CIIID Winter Quarter Seminar: Daniel W. McVicar, Ph.D.

Presenter:  Daniel W. McVicar, Ph.D., Deputy Director, Center for Cancer Research, National Cancer Institute, Frederick, MD

Talk Title:  "Metabolic Adaptations to Tumor-associated Niches"

Summary:

Immunometabolism has been studied largely independently, when arguably it is most relevant when considered in the context of specific physiological niches.  Recently, our laboratory has been evaluating the peritoneal cavity as a physiological niche.  Our work has identified adaptive metabolic programming in resident macrophages in the peritoneum and examined their adaptation to cancer.  In dissecting this relationship, we have uncovered an intriguing metabolic adaptation of neutrophils in response to tumor-derived factors.  Together our data highlight the metabolic adaptation of innate immune cells to an anatomical niche, as well as to alterations in the niche during cancer progression.