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Toll-like receptor stimulation induces higher TNF-alpha secretion in peripheral blood mononuclear cells from patients with hyper IgE syndrome.
| Title | Toll-like receptor stimulation induces higher TNF-alpha secretion in peripheral blood mononuclear cells from patients with hyper IgE syndrome. |
| Publication Type | Journal Article |
| Year of Publication | 2008 |
| Authors | Yeganeh, M, Henneke, P, Rezaei, N, Ehl, S, Thiel, D, Matamoros, N, Pietrogrande, C, Espanol, T, Litzman, J, Franco, JL, Sanal, O, Kilic, SS, Breborowicz, A, Plebani, A, Renner, E, Rothenfusser, S, Hawn, TR, Woellner, C, Grimbacher, B |
| Journal | Int Arch Allergy Immunol |
| Volume | 146 |
| Issue | 3 |
| Pagination | 190-4 |
| Date Published | 2008 |
| ISSN | 1423-0097 |
| Keywords | Cohort Studies, Female, Humans, Interleukin-8, Job's Syndrome, Leukocytes, Mononuclear, Lipopolysaccharides, Male, Signal Transduction, Statistics, Nonparametric, Toll-Like Receptor 2, Toll-Like Receptor 4, Tumor Necrosis Factor-alpha |
| Abstract | Hyper IgE syndromes (HIES) are primary immunodeficiency disorders of unknown pathogenesis. Patients are typically affected with 'cold' abscesses of the skin, recurrent cyst-forming pneumonia, chronic mucocutaneous candidiasis and other less frequent features such as progressive skeletal abnormalities. Defective signaling in the Toll-like receptor (TLR) pathways has been suggested as a responsible pathologic mechanism, however, in previous reports, 10 patients revealed no defect in inflammatory cytokine responses to different TLR ligands. Here, we report the increase in pro-inflammatory cytokines TNF-alpha and IL-8, following TLR2 and TLR4 stimulation in a larger cohort of 25 additional patients with HIES, and provide a meta-analysis of the TLR data in HIES. |
| DOI | 10.1159/000115886 |
| Alternate Journal | Int. Arch. Allergy Immunol. |
| PubMed ID | 18268386 |
