You are here

Home » Selection for simple major surface protein 2 variants during Anaplasma marginale transmission to immunologically naïve animals.

Selection for simple major surface protein 2 variants during Anaplasma marginale transmission to immunologically naïve animals.

TitleSelection for simple major surface protein 2 variants during Anaplasma marginale transmission to immunologically naïve animals.
Publication TypeJournal Article
Year of Publication2007
AuthorsPalmer, GH, Futse, JE, Leverich, CK, Knowles, DP, Rurangirwa, FR, Brayton, KA
JournalInfect Immun
Volume75
Issue3
Pagination1502-6
Date Published2007 Mar
ISSN0019-9567
KeywordsAnaplasma marginale, Anaplasmosis, Animals, Antigens, Bacterial, Bacterial Outer Membrane Proteins, Cattle, Dermacentor, Immunity, Innate, Male
Abstract

Anaplasma marginale, a rickettsial pathogen, evades clearance in the animal host by antigenic variation. Under immune selection, A. marginale expresses complex major surface protein 2 mosaics, derived from multiple donor sequences. However, these mosaics have a selective advantage only in the presence of adaptive immunity and are rapidly replaced by simple variants following transmission.
DOI10.1128/IAI.01801-06
Alternate JournalInfect. Immun.
PubMed ID17178787
PubMed Central IDPMC1828556
Grant ListR01 AI44005 / AI / NIAID NIH HHS / United States