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Home ยป Infectious clones of novel lineage 1 and lineage 2 West Nile virus strains WNV-TX02 and WNV-Madagascar.

Infectious clones of novel lineage 1 and lineage 2 West Nile virus strains WNV-TX02 and WNV-Madagascar.

TitleInfectious clones of novel lineage 1 and lineage 2 West Nile virus strains WNV-TX02 and WNV-Madagascar.
Publication TypeJournal Article
Year of Publication2012
AuthorsSuthar, MS, Brassil, MM, Blahnik, G, Gale, M
JournalJ Virol
Volume86
Issue14
Pagination7704-9
Date Published2012 Jul
ISSN1098-5514
KeywordsAnimals, Cell Line, Cricetinae, Interferon Type I, Mice, Mice, Transgenic, Phosphorylation, STAT1 Transcription Factor, STAT2 Transcription Factor, Viral Nonstructural Proteins, Viral Structural Proteins, West Nile Fever, West Nile virus
Abstract

We report the generation of West Nile virus (WNV) infectious clones for the pathogenic lineage 1 Texas-HC2002 and nonpathogenic lineage 2 Madagascar-AnMg798 strains. The infectious clones exhibited biological properties similar to those of the parental virus isolates. We generated chimeric viruses and found that viral factors within the structural and nonstructural regions of WNV-TX contribute to the control of type I interferon defenses. These infectious clones provide new reagents to study flavivirus immune regulation and pathogenesis.
DOI10.1128/JVI.00401-12
Alternate JournalJ. Virol.
PubMed ID22573862