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Home ยป Identification of immunodominant polypeptides common between Anaplasma centrale and Anaplasma marginale.

Identification of immunodominant polypeptides common between Anaplasma centrale and Anaplasma marginale.

TitleIdentification of immunodominant polypeptides common between Anaplasma centrale and Anaplasma marginale.
Publication TypeJournal Article
Year of Publication1991
AuthorsShkap, V, Pipano, E, McGuire, TC, Palmer, GH
JournalVet Immunol Immunopathol
Volume29
Issue1-2
Pagination31-40
Date Published1991 Aug
ISSN0165-2427
KeywordsAnaplasma, Anaplasmosis, Animals, Antibodies, Bacterial, Antigens, Bacterial, Bacterial Proteins, Cattle, Cross Reactions, Electrophoresis, Polyacrylamide Gel, Enzyme-Linked Immunosorbent Assay, Immunoblotting, Immunodominant Epitopes, Molecular Weight, Rabbits
Abstract

High titered antibody from rabbits immunized with Anaplasma centrale or from cattle recovered from A. centrale infection bound predominantly to several 33-36 kDa polypeptides present in both A. centrale and the Israel-NT isolate of Anaplasma marginale. High titered bovine antibody against the Israel-NT isolate of A. marginale also reacted predominantly with A. centrale polypeptides in this size range. The immunodominance of the 33-36 kDa polypeptides and their cross-reactivity indicate that these shared epitopes may be primarily responsible for the cross-protective immunity between A. centrale and A. marginale.
Alternate JournalVet. Immunol. Immunopathol.
PubMed ID1949581