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Fas/FADD-mediated activation of a specific program of inflammatory gene expression in vascular smooth muscle cells.
Title | Fas/FADD-mediated activation of a specific program of inflammatory gene expression in vascular smooth muscle cells. |
Publication Type | Journal Article |
Year of Publication | 2000 |
Authors | Schaub, FJ, Han, DK, Liles, WC, Adams, LD, Coats, SA, Ramachandran, RK, Seifert, RA, Schwartz, SM, Bowen-Pope, DF |
Journal | Nat Med |
Volume | 6 |
Issue | 7 |
Pagination | 790-6 |
Date Published | 2000 Jul |
ISSN | 1078-8956 |
Keywords | Adaptor Proteins, Signal Transducing, Animals, Antigens, CD95, Apoptosis, Carotid Arteries, Carrier Proteins, Caspases, Chemokine CCL2, Fas-Associated Death Domain Protein, Gene Expression Regulation, Humans, Inflammation, Interleukin-1, Interleukin-8, Muscle, Smooth, Vascular, Rats, Rats, Inbred F344, Up-Regulation |
Abstract | Apoptosis of smooth muscle cells is a common feature of vascular lesions but its pathophysiological significance is not known. We demonstrate that signals initiated by regulated Fas-associated death domain protein overexpression in rat vascular smooth muscle cells in the carotid artery induce expression of monocyte-chemoattractant protein-1 and interleukin-8, and cause massive immigration of macrophages in vivo. These chemokines, and a specific set of other pro-inflammatory genes, are also upregulated in human vascular smooth muscle cells during Fas-induced apoptosis, in part through a process that requires interleukin-1alpha activation. Induction of a pro-inflammatory program by apoptotic vascular smooth muscle cells may thus contribute to the pathogenesis of vascular disease. |
DOI | 10.1038/77521 |
Alternate Journal | Nat. Med. |
PubMed ID | 10888928 |