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The evolution of vertebrate Toll-like receptors.
| Title | The evolution of vertebrate Toll-like receptors. |
| Publication Type | Journal Article |
| Year of Publication | 2005 |
| Authors | Roach, JC, Glusman, G, Rowen, L, Kaur, A, Purcell, MK, Smith, KD, Hood, LE, Aderem, A |
| Journal | Proc Natl Acad Sci U S A |
| Volume | 102 |
| Issue | 27 |
| Pagination | 9577-82 |
| Date Published | 2005 Jul 5 |
| ISSN | 0027-8424 |
| Keywords | Animals, Base Sequence, Computational Biology, Evolution, Molecular, Gene Components, Genomics, Membrane Glycoproteins, Models, Genetic, Molecular Sequence Data, Multigene Family, Phylogeny, Receptors, Cell Surface, Sequence Analysis, DNA, Species Specificity, Takifugu, Toll-Like Receptor 1, Toll-Like Receptors, Vertebrates |
| Abstract | The complete sequences of Takifugu Toll-like receptor (TLR) loci and gene predictions from many draft genomes enable comprehensive molecular phylogenetic analysis. Strong selective pressure for recognition of and response to pathogen-associated molecular patterns has maintained a largely unchanging TLR recognition in all vertebrates. There are six major families of vertebrate TLRs. This repertoire is distinct from that of invertebrates. TLRs within a family recognize a general class of pathogen-associated molecular patterns. Most vertebrates have exactly one gene ortholog for each TLR family. The family including TLR1 has more species-specific adaptations than other families. A major family including TLR11 is represented in humans only by a pseudogene. Coincidental evolution plays a minor role in TLR evolution. The sequencing phase of this study produced finished genomic sequences for the 12 Takifugu rubripes TLRs. In addition, we have produced >70 gene models, including sequences from the opossum, chicken, frog, dog, sea urchin, and sea squirt. |
| DOI | 10.1073/pnas.0502272102 |
| Alternate Journal | Proc. Natl. Acad. Sci. U.S.A. |
| PubMed ID | 15976025 |
