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Characterization of two divergent lineages of macaque rhadinoviruses related to Kaposi's sarcoma-associated herpesvirus.
Title | Characterization of two divergent lineages of macaque rhadinoviruses related to Kaposi's sarcoma-associated herpesvirus. |
Publication Type | Journal Article |
Year of Publication | 2000 |
Authors | Schultz, ER, Rankin, GW, Blanc, MP, Raden, BW, Tsai, CC, Rose, TM |
Journal | J Virol |
Volume | 74 |
Issue | 10 |
Pagination | 4919-28 |
Date Published | 2000 May |
ISSN | 0022-538X |
Keywords | Amino Acid Sequence, Animals, Base Sequence, Cloning, Molecular, DNA-Directed DNA Polymerase, Evolution, Molecular, Gammaherpesvirinae, Herpesvirus 8, Human, Humans, Macaca mulatta, Macaca nemestrina, Molecular Sequence Data, Monkey Diseases, Open Reading Frames, Phylogeny, Retroperitoneal Fibrosis, Sarcoma, Kaposi, Viral Envelope Proteins |
Abstract | We have cloned and characterized the entire DNA polymerase gene and flanking regions from Kaposi's sarcoma-associated herpesvirus (KSHV) and two closely related macaque homologs of KSHV, retroperitoneal fibromatosis-associated herpesvirus-Macaca nemestrina (RFHVMn) and -Macaca mulatta (RFHVMm). We have also identified and partially characterized the corresponding genomic region of another KSHV-like herpesvirus, provisionally named "M. nemestrina rhadinovirus type 2 (MneRV-2)," with close similarity to rhesus rhadinovirus (RRV). A sequence comparison of these four macaque viruses and two KSHV-like gammaherpesviruses recently identified in African green monkeys, Chlorocebus rhadinovirus types 1 and 2 (ChRV-1 and ChRV-2) reveals the presence of two distinct lineages of KSHV-like rhadinoviruses in Old World primates. The first rhadinovirus lineage consists of KSHV and its closely related homologs RFHVMn, RFHVMm, and ChRV-1, while the second more distantly related lineage consists of RRV, MneRV-2, and ChRV-2. Our findings raise the possibility of the existence of another human KSHV-like herpesvirus belonging to the second rhadinovirus lineage. |
Alternate Journal | J. Virol. |
PubMed ID | 10775636 |
PubMed Central ID | PMC112020 |
Grant List | R01-RR13154 / RR / NCRR NIH HHS / United States R55-CA72237-01 / CA / NCI NIH HHS / United States |