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CD4+ T cells and toll-like receptors recognize Salmonella antigens expressed in bacterial surface organelles.
| Title | CD4+ T cells and toll-like receptors recognize Salmonella antigens expressed in bacterial surface organelles. |
| Publication Type | Journal Article |
| Year of Publication | 2005 |
| Authors | Bergman, MA, Cummings, LA, Barrett, SLRassouli, Smith, KD, J Lara, C, Aderem, A, Cookson, BT |
| Journal | Infect Immun |
| Volume | 73 |
| Issue | 3 |
| Pagination | 1350-6 |
| Date Published | 2005 Mar |
| ISSN | 0019-9567 |
| Keywords | Animals, Antigens, Bacterial, Bacterial Proteins, CD4-Positive T-Lymphocytes, Cell Membrane, Female, Flagella, Gene Expression Regulation, Bacterial, Ligands, Lymphocyte Activation, Membrane Glycoproteins, Mice, Mice, Inbred C3H, Mice, Inbred C57BL, Organelles, Receptors, Cell Surface, Salmonella Infections, Animal, Salmonella typhimurium, Toll-Like Receptors, Virulence |
| Abstract | A better understanding of immunity to infection is revealed from the characteristics of microbial ligands recognized by host immune responses. Murine infection with the intracellular bacterium Salmonella generates CD4+ T cells that specifically recognize Salmonella proteins expressed in bacterial surface organelles such as flagella and membrane vesicles. These natural Salmonella antigens are also ligands for Toll-like receptors (TLRs) or avidly associated with TLR ligands such as lipopolysaccharide (LPS). PhoP/PhoQ, a regulon controlling Salmonella virulence and remodeling of LPS to resist innate immunity, coordinately represses production of surface-exposed antigens recognized by CD4+ T cells and TLRs. These data suggest that genetically coordinated surface modifications may provide a growth advantage for Salmonella in host tissues by limiting both innate and adaptive immune recognition. |
| DOI | 10.1128/IAI.73.3.1350-1356.2005 |
| Alternate Journal | Infect. Immun. |
| PubMed ID | 15731032 |
