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Antigens of Treponema pallidum recognized by IgG and IgM antibodies during syphilis in humans.
Title | Antigens of Treponema pallidum recognized by IgG and IgM antibodies during syphilis in humans. |
Publication Type | Journal Article |
Year of Publication | 1985 |
Authors | Baker-Zander, SA, Hook, EW, Bonin, P, Handsfield, HH, Lukehart, SA |
Journal | J Infect Dis |
Volume | 151 |
Issue | 2 |
Pagination | 264-72 |
Date Published | 1985 Feb |
ISSN | 0022-1899 |
Keywords | Antibodies, Bacterial, Antibody Specificity, Antigens, Bacterial, False Positive Reactions, Humans, Immunoglobulin G, Immunoglobulin M, Syphilis, Syphilis, Latent, Treponema pallidum |
Abstract | IgG and IgM antibody specificities for antigens of Treponema pallidum Nichols strain were determined by using sodium dodecyl sulfate-polyacrylamide gel electrophoresis and the western blot technique in sera from patients with untreated syphilis, normal persons, persons with biologic false-positive tests for syphilis, and sexual contacts of persons with infectious syphilis. IgG reactivities of sera from individuals with primary syphilis varied considerably but consistently exhibited strong reactivity to a 48-kilodalton band. Sera from patients with secondary and early latent syphilis uniformly demonstrated reactivity to 22 separate polypeptide antigens; decreased reactivity was seen in late latent syphilis. Normal and biologic false-positive sera showed weak IgG reactivity against none to 12 polypeptides. Sera from asymptomatic contacts of persons with infectious syphilis showed reactivity to a varying number of treponemal antigens, including some reactions not seen with normal sera. IgM reactivity was most prominent in secondary syphilis but was demonstrable at all stages of disease. |
Alternate Journal | J. Infect. Dis. |
PubMed ID | 3881539 |
Grant List | AI-12192 / AI / NIAID NIH HHS / United States AI-18988 / AI / NIAID NIH HHS / United States |