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CERID Bibliography
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Author Title Type [ Year] Filters: Keyword is Plasmodium berghei [Clear All Filters]
Bioisosteric transformations and permutations in the triazolopyrimidine scaffold to identify the minimum pharmacophore required for inhibitory activity against Plasmodium falciparum dihydroorotate dehydrogenase. J Med Chem. 2012 ;55(17):7425-36.
. Transmission of malaria to mosquitoes blocked by bumped kinase inhibitors. J Clin Invest. 2012 ;122(6):2301-5.
Inhaled nitric oxide reduces endothelial activation and parasite accumulation in the brain, and enhances survival in experimental cerebral malaria. PLoS One. 2011 ;6(11):e27714.
. Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice. J Med Chem. 2011 ;54(11):3935-49.
S1P is associated with protection in human and experimental cerebral malaria. Mol Med. 2011 ;17(7-8):717-25.
. Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice. J Med Chem. 2009 ;52(7):1864-72.
Statins fail to improve outcome in experimental cerebral malaria and potentiate Toll-like receptor-mediated cytokine production by murine macrophages. Am J Trop Med Hyg. 2009 ;81(4):631-7.
. Failure of two distinct anti-apoptotic approaches to reduce mortality in experimental cerebral malaria. Am J Trop Med Hyg. 2008 ;79(6):823-5.
. Parasite burden and CD36-mediated sequestration are determinants of acute lung injury in an experimental malaria model. PLoS Pathog. 2008 ;4(5):e1000068.
. Efficacy, pharmacokinetics, and metabolism of tetrahydroquinoline inhibitors of Plasmodium falciparum protein farnesyltransferase. Antimicrob Agents Chemother. 2007 ;51(10):3659-71.
Expression microarray analysis implicates apoptosis and interferon-responsive mechanisms in susceptibility to experimental cerebral malaria. Am J Pathol. 2007 ;171(6):1894-903.
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Protein farnesyltransferase inhibitors exhibit potent antimalarial activity. J Med Chem. 2005 ;48(11):3704-13.
In vitro and in vivo antimalarial activity of peptidomimetic protein farnesyltransferase inhibitors with improved membrane permeability. Bioorg Med Chem. 2004 ;12(24):6517-26.