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Viral regulation and evasion of the host response.
Title | Viral regulation and evasion of the host response. |
Publication Type | Journal Article |
Year of Publication | 2007 |
Authors | Loo, YM, Gale, M |
Journal | Curr Top Microbiol Immunol |
Volume | 316 |
Pagination | 295-313 |
Date Published | 2007 |
ISSN | 0070-217X |
Keywords | Animals, Hepacivirus, Hepatitis C, Host-Pathogen Interactions, Humans, Immunity, Innate, Interferon Type I |
Abstract | The type I interferons (IFN) are cytokines produced by mammalian cells in response to virus infection or other stressors. IFNs exert antiviral function by binding to the IFNalpha/beta receptors on the cell surface, with the major effect of triggering the JAK-STAT signaling cascade and inducing the expression of interferon-stimulated genes. The resulting innate antiviral response is a first line of immune defense against virus infection. Recent studies demonstrate that many viruses, including hepatitis C virus, direct processes to control the host response to infection. We provide a review of the virus/host processes involved in IFN signaling and regulation of innate immune defenses. |
Alternate Journal | Curr. Top. Microbiol. Immunol. |
PubMed ID | 17969453 |