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Trypanosome and animal lanosterol synthases use different catalytic motifs.
| Title | Trypanosome and animal lanosterol synthases use different catalytic motifs. |
| Publication Type | Journal Article |
| Year of Publication | 2001 |
| Authors | Joubert, BM, Buckner, FS, Matsuda, SP |
| Journal | Org Lett |
| Volume | 3 |
| Issue | 12 |
| Pagination | 1957-60 |
| Date Published | 2001 Jun 14 |
| ISSN | 1523-7060 |
| Keywords | Amino Acid Motifs, Amino Acid Sequence, Animals, Catalytic Domain, Humans, Intramolecular Transferases, Molecular Sequence Data, Sequence Homology, Amino Acid, Trypanosoma cruzi |
| Abstract | [see reaction]. Animals, fungi, and some protozoa convert oxidosqualene to lanosterol in the ring-forming reaction in sterol biosynthesis. The Trypanosoma cruzi lanosterol synthase has now been cloned. The sequence shares with the T. brucei lanosterol synthase a tyrosine substitution for the catalytically important active-site threonine found in animal and fungal lanosterol synthases. |
| Alternate Journal | Org. Lett. |
| PubMed ID | 11405754 |
