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Home ยป The transcriptional regulator SoxS is required for resistance of Salmonella typhimurium to paraquat but not for virulence in mice.

The transcriptional regulator SoxS is required for resistance of Salmonella typhimurium to paraquat but not for virulence in mice.

TitleThe transcriptional regulator SoxS is required for resistance of Salmonella typhimurium to paraquat but not for virulence in mice.
Publication TypeJournal Article
Year of Publication1997
AuthorsFang, FC, Vazquez-Torres, A, Xu, Y
JournalInfect Immun
Volume65
Issue12
Pagination5371-5
Date Published1997 Dec
ISSN0019-9567
KeywordsAnimals, Bacterial Proteins, Drug Resistance, Microbial, Escherichia coli, Escherichia coli Proteins, Gene Expression Regulation, Bacterial, Mice, Paraquat, Salmonella Infections, Animal, Salmonella typhimurium, Species Specificity, Trans-Activators, Transcription Factors, Virulence
Abstract

In Escherichia coli, the SoxRS regulon is required for resistance to redox-cycling agents which elevate cytosolic superoxide levels, as well as for resistance to nitric oxide-dependent macrophage killing. In Salmonella typhimurium, SoxS is also required for enhanced expression of Mn-superoxide dismutase and resistance to paraquat, but not for resistance to nitric oxide donor compounds in vitro, resistance to macrophage killing, or virulence in mice. Differences in other antioxidant defense systems or compensation by homologous regulons may account for species-specific differences in the role of SoxS.
Alternate JournalInfect. Immun.
PubMed ID9393844
PubMed Central IDPMC175777
Grant ListAI32463 / AI / NIAID NIH HHS / United States
AI39557 / AI / NIAID NIH HHS / United States