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Trafficking of superinfecting Mycobacterium organisms into established granulomas occurs in mammals and is independent of the Erp and ESX-1 mycobacterial virulence loci.
Title | Trafficking of superinfecting Mycobacterium organisms into established granulomas occurs in mammals and is independent of the Erp and ESX-1 mycobacterial virulence loci. |
Publication Type | Journal Article |
Year of Publication | 2008 |
Authors | Cosma, CL, Humbert, O, Sherman, DR, Ramakrishnan, L |
Journal | J Infect Dis |
Volume | 198 |
Issue | 12 |
Pagination | 1851-5 |
Date Published | 2008 Dec 15 |
ISSN | 0022-1899 |
Keywords | Animals, Bacterial Proteins, Chemotaxis, Female, Gene Expression Regulation, Bacterial, Granuloma, Mice, Mice, Inbred C57BL, Mycobacterium bovis, Mycobacterium Infections, Mycobacterium tuberculosis, Superinfection, Virulence |
Abstract | Although tuberculous granulomas, which are composed of infected macrophages and other immune cells, have long been considered impermeable structures, recent studies have shown that superinfecting Mycobacterium marinum traffic rapidly to established fish and frog granulomas by host-mediated and Mycobacterium-directed mechanisms. The present study shows that superinfecting Mycobacterium tuberculosis and Mycobacterium bovis bacille Calmette-Guérin similarly home to established granulomas in mice. Furthermore, 2 prominent mycobacterial virulence determinants, Erp and ESX-1, do not affect this cellular trafficking. These findings suggest that homing of infected macrophages to sites of infection is a general feature of the pathogenesis of tuberculosis and has important consequences for therapeutic strategies. |
DOI | 10.1086/593175 |
Alternate Journal | J. Infect. Dis. |
PubMed ID | 18983252 |
PubMed Central ID | PMC2644660 |
Grant List | AI36396 / AI / NIAID NIH HHS / United States HL64550 / HL / NHLBI NIH HHS / United States R01 AI036396-15 / AI / NIAID NIH HHS / United States R01 HL064550-05 / HL / NHLBI NIH HHS / United States |