You are here
Therapeutic use of cytokines to modulate phagocyte function for the treatment of infectious diseases: current status of granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, macrophage colony-stimulating factor, and inte
Title | Therapeutic use of cytokines to modulate phagocyte function for the treatment of infectious diseases: current status of granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, macrophage colony-stimulating factor, and inte |
Publication Type | Journal Article |
Year of Publication | 2002 |
Authors | Hübel, K, Dale, DC, W Liles, C |
Journal | J Infect Dis |
Volume | 185 |
Issue | 10 |
Pagination | 1490-501 |
Date Published | 2002 May 15 |
ISSN | 0022-1899 |
Keywords | Animals, Chills, Clinical Trials as Topic, Communicable Diseases, Disease Models, Animal, Fever, Granulocyte Colony-Stimulating Factor, Granulocyte-Macrophage Colony-Stimulating Factor, Headache, Humans, Interferon-gamma, Macrophage Colony-Stimulating Factor, Pain, Phagocytes, Thrombocytopenia |
Abstract | The innate immune system represents the initial arm of host defense against pathogenic bacteria, fungi, and parasites. Neutrophils, monocytes, and tissue-based macrophages are major cellular components of this system. The potential ability to augment activity of the innate immune system has increased dramatically during the past 2 decades, with the discovery and development of cytokines. Four cytokines, namely granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), macrophage colony-stimulating factor (M-CSF), and interferon (IFN)-gamma, have received increasing attention as potential adjunctive agents for the treatment of infectious diseases. In various animal models of infection, therapeutic administration of each of the 4 cytokines has been shown to enhance pathogen eradication and to decrease morbidity and/or mortality. However, variable therapeutic efficacy has been reported in clinical trials conducted to date. This review summarizes the current status of the use of G-CSF, GM-CSF, M-CSF, and IFN-gamma in the treatment of infectious diseases. |
DOI | 10.1086/340221 |
Alternate Journal | J. Infect. Dis. |
PubMed ID | 11992286 |