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TB: the Yin and Yang of lipid mediators.
Title | TB: the Yin and Yang of lipid mediators. |
Publication Type | Journal Article |
Year of Publication | 2013 |
Authors | Tobin, DM, Ramakrishnan, L |
Journal | Curr Opin Pharmacol |
Volume | 13 |
Issue | 4 |
Pagination | 641-5 |
Date Published | 2013 Aug |
ISSN | 1471-4973 |
Abstract | There is a growing appreciation of the diverse roles that lipid mediators play in modulating inflammatory responses during infection. In the case of tuberculosis, virulent mycobacteria induce host production of anti-inflammatory mediators, including lipoxins, which limit the host inflammatory response and lead to necrotic cell death of infected macrophages. Recent work using the zebrafish model suggests that, while excess anti-inflammatory lipoxins are host detrimental during mycobacterial infections, excess pro-inflammatory lipids also drive host susceptibility. The balance of these inflammatory states is influenced by common human genetic variation in Asia. Fuller understanding of the mechanisms of eicosanoid-mediated inflammatory imbalance during tuberculosis infection has important implications for the development of adjunctive therapies. |
DOI | 10.1016/j.coph.2013.06.007 |
Alternate Journal | Curr Opin Pharmacol |
PubMed ID | 23849093 |
PubMed Central ID | PMC3756664 |
Grant List | DP1 MH099901 / MH / NIMH NIH HHS / United States DP2 OD008614 / OD / NIH HHS / United States |