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Syphilis: using modern approaches to understand an old disease.
Title | Syphilis: using modern approaches to understand an old disease. |
Publication Type | Journal Article |
Year of Publication | 2011 |
Authors | Ho, EL, Lukehart, SA |
Journal | J Clin Invest |
Volume | 121 |
Issue | 12 |
Pagination | 4584-92 |
Date Published | 2011 Dec |
ISSN | 1558-8238 |
Keywords | Animals, Anti-Bacterial Agents, Antibodies, Bacterial, Bacterial Typing Techniques, Bacterial Vaccines, Comorbidity, Drug Resistance, Microbial, Female, HIV Infections, Host-Pathogen Interactions, Humans, Male, Morbidity, Penicillins, Rabbits, Syphilis, Syphilis Serodiagnosis, Treponema pallidum, World Health |
Abstract | Syphilis is a fascinating and perplexing infection, with protean clinical manifestations and both diagnostic and management ambiguities. Treponema pallidum subsp. pallidum, the agent of syphilis, is challenging to study in part because it cannot be cultured or genetically manipulated. Here, we review recent progress in the application of modern molecular techniques to understanding the biological basis of this multistage disease and to the development of new tools for diagnosis, for predicting efficacy of treatment with alternative antibiotics, and for studying the transmission of infection through population networks. |
DOI | 10.1172/JCI57173 |
Alternate Journal | J. Clin. Invest. |
PubMed ID | 22133883 |
PubMed Central ID | PMC3225993 |
Grant List | R01 AI042143 / AI / NIAID NIH HHS / United States R01 AI063940 / AI / NIAID NIH HHS / United States R01 AI42143 / AI / NIAID NIH HHS / United States R01 AI63940 / AI / NIAID NIH HHS / United States R03 AI094122 / AI / NIAID NIH HHS / United States T32 AI007140 / AI / NIAID NIH HHS / United States |