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Silencing of xenogeneic DNA by H-NS-facilitation of lateral gene transfer in bacteria by a defense system that recognizes foreign DNA.
Title | Silencing of xenogeneic DNA by H-NS-facilitation of lateral gene transfer in bacteria by a defense system that recognizes foreign DNA. |
Publication Type | Journal Article |
Year of Publication | 2007 |
Authors | Navarre, WWiley, McClelland, M, Libby, SJ, Fang, FC |
Journal | Genes Dev |
Volume | 21 |
Issue | 12 |
Pagination | 1456-71 |
Date Published | 2007 Jun 15 |
ISSN | 0890-9369 |
Keywords | Bacteria, Bacterial Proteins, Base Composition, DNA, Bacterial, DNA-Binding Proteins, Gene Expression Regulation, Bacterial, Gene Silencing, Gene Transfer Techniques, Gene Transfer, Horizontal, Genes, Bacterial, Interspersed Repetitive Sequences, Models, Genetic |
Abstract | Lateral gene transfer has played a prominent role in bacterial evolution, but the mechanisms allowing bacteria to tolerate the acquisition of foreign DNA have been incompletely defined. Recent studies show that H-NS, an abundant nucleoid-associated protein in enteric bacteria and related species, can recognize and selectively silence the expression of foreign DNA with higher adenine and thymine content relative to the resident genome, a property that has made this molecule an almost universal regulator of virulence determinants in enteric bacteria. These and other recent findings challenge the ideas that curvature is the primary determinant recognized by H-NS and that activation of H-NS-silenced genes in response to environmental conditions occurs through a change in the structure of H-NS itself. Derepression of H-NS-silenced genes can occur at specific promoters by several mechanisms including competition with sequence-specific DNA-binding proteins, thereby enabling the regulated expression of foreign genes. The possibility that microorganisms maintain and exploit their characteristic genomic GC ratios for the purpose of self/non-self-discrimination is discussed. |
DOI | 10.1101/gad.1543107 |
Alternate Journal | Genes Dev. |
PubMed ID | 17575047 |
Grant List | AI34829 / AI / NIAID NIH HHS / United States AI39557 / AI / NIAID NIH HHS / United States AI44486 / AI / NIAID NIH HHS / United States AI52237 / AI / NIAID NIH HHS / United States AI57733 / AI / NIAID NIH HHS / United States |