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The role of person-to-person transmission in an epidemiologic study of Pneumocystis carinii pneumonia.
Title | The role of person-to-person transmission in an epidemiologic study of Pneumocystis carinii pneumonia. |
Publication Type | Journal Article |
Year of Publication | 2002 |
Authors | Wohl, ARock, Simon, P, Hu, YWei, Duchin, JS |
Journal | AIDS |
Volume | 16 |
Issue | 13 |
Pagination | 1821-5 |
Date Published | 2002 Sep 6 |
ISSN | 0269-9370 |
Keywords | Adult, Aged, AIDS-Related Opportunistic Infections, Case-Control Studies, CD4 Lymphocyte Count, Contact Tracing, Disease Transmission, Infectious, Female, HIV Infections, Humans, Los Angeles, Male, Middle Aged, Pneumocystis, Pneumonia, Pneumocystis, Questionnaires, Risk Factors, Washington |
Abstract | OBJECTIVE: Recent laboratory studies suggest that may be transmitted from person-to-person. Recent exposure to persons with pneumonia (PCP) among HIV-infected persons with and without PCP was assessed to evaluate the person-to-person transmission hypothesis. DESIGN: A case-control study design was used. METHODS: In Seattle and Los Angeles, a history of contact with persons with PCP was compared between HIV-infected patients with laboratory-confirmed PCP (n = 209) and HIV-infected patients with no history of PCP (n = 254). RESULTS: No association was found between past exposures to persons with PCP and an increased odds for PCP [odds ratio (OR), 0.6; 95% confidence interval (CI), 0.3-1.1] in the total study group. In addition, no association was observed when the analysis was restricted to cases and controls who were not on adequate PCP prophylaxis in the previous 3 months (OR, 0.7; 95% CI, 0.3-1.5). Most cases in Los Angeles (95%) and Seattle (96%) were not receiving PCP prophylaxis in the 3 months prior to a PCP diagnosis. Many controls in Los Angeles (54%) and Seattle (47%) were also not on prophylaxis. In addition, 23% of the Seattle cases and 42% of the Los Angeles cases were unaware of their HIV infection at the time of their PCP diagnosis. CONCLUSIONS: Although most participants were not on adequate prophylaxis, we found no evidence of person-to-person transmission of Pneumocystis carinii in a population with advanced HIV disease. The difficulty quantifying past exposures to persons with PCP is a limitation of this type of research. |
Alternate Journal | AIDS |
PubMed ID | 12218395 |