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Repeat-region polymorphisms in the gene for the dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin-related molecule: effects on HIV-1 susceptibility.
| Title | Repeat-region polymorphisms in the gene for the dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin-related molecule: effects on HIV-1 susceptibility. |
| Publication Type | Journal Article |
| Year of Publication | 2006 |
| Authors | Liu, H, Carrington, M, Wang, C, Holte, S, Lee, J, Greene, B, Hladik, F, Koelle, DM, Wald, A, Kurosawa, K, Rinaldo, CR, Celum, C, Detels, R, Corey, L, McElrath, JM, Zhu, T |
| Journal | J Infect Dis |
| Volume | 193 |
| Issue | 5 |
| Pagination | 698-702 |
| Date Published | 2006 Mar 1 |
| ISSN | 0022-1899 |
| Keywords | Cell Adhesion Molecules, Cohort Studies, Genetic Predisposition to Disease, Genotype, HIV Infections, HIV Seropositivity, HIV-1, Humans, Lectins, C-Type, Polymorphism, Genetic, Receptors, Cell Surface, Repetitive Sequences, Nucleic Acid |
| Abstract | In 1716 individuals--801 human immunodeficiency virus (HIV)-1-seropositive individuals, 217 high-risk HIV-1-seronegative individuals, and 698 general HIV-1-seronegative individuals--from a Seattle cohort and a Multicenter AIDS Cohort Study cohort, the association between HIV-1 susceptibility and repeat-region polymorphisms in the gene for the dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin-related molecule (DC-SIGNR) was investigated; 16 genotypes were found in the DC-SIGNR repeat region. The DC-SIGNR homozygous 7/7 repeat was found to be associated with an increased risk of HIV-1 infection (17.5% in high-risk HIV-1-seronegative individuals vs. 28.5% in HIV-1-seropositive individuals; P=.0015), whereas the DC-SIGNR heterozygous 7/5 repeat tended to be correlated with resistance to HIV-1 infection (35.5% in high-risk HIV-1-seronegative individuals vs. 27.6% in HIV-1-seropositive individuals; P=.0291). These findings suggest that DC-SIGNR polymorphisms may influence susceptibility to HIV-1. |
| DOI | 10.1086/499820 |
| Alternate Journal | J. Infect. Dis. |
| PubMed ID | 16453266 |
