You are here

Home ยป Recombinant Listeria monocytogenes expressing an immunodominant peptide fails to protect after intravaginal challenge with herpes simplex virus-2.

Recombinant Listeria monocytogenes expressing an immunodominant peptide fails to protect after intravaginal challenge with herpes simplex virus-2.

TitleRecombinant Listeria monocytogenes expressing an immunodominant peptide fails to protect after intravaginal challenge with herpes simplex virus-2.
Publication TypeJournal Article
Year of Publication2008
AuthorsMuller, WJ, Orgun, NN, Dong, L, Koelle, DM, Huang, M-L, Way, SS
JournalArch Virol
Volume153
Issue6
Pagination1165-9
Date Published2008
ISSN0304-8608
KeywordsAnimals, CD8-Positive T-Lymphocytes, Female, Herpes Genitalis, Herpes Simplex Virus Vaccines, Herpesvirus 2, Human, Immunodominant Epitopes, Injections, Intravenous, Listeria monocytogenes, Mice, Mice, Inbred C57BL, Recombination, Genetic, Simplexvirus, T-Cell Antigen Receptor Specificity, Vaccination, Vaccines, Synthetic, Viral Envelope Proteins
Abstract

Recombinant Listeria monocytogenes expressing a type-common herpes simplex virus (HSV) gB-peptide was shown previously to protect against footpad inoculation with HSV-1. We tested this construct for protection against vaginal challenge with HSV-2. Primed mice demonstrated strong recall responses, had modest reductions in HSV-2 DNA in vaginal mucosa, but were not protected from disease.
DOI10.1007/s00705-008-0089-7
Alternate JournalArch. Virol.
PubMed ID18443737