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Home ยป Protection against gram-negative infections with antiserum to lipid A from Salmonella minnesota R595.

Protection against gram-negative infections with antiserum to lipid A from Salmonella minnesota R595.

TitleProtection against gram-negative infections with antiserum to lipid A from Salmonella minnesota R595.
Publication TypeJournal Article
Year of Publication1974
AuthorsMullan, NA, Newsome, PM, Cunnington, PG, Palmer, GH, Wilson, ME
JournalInfect Immun
Volume10
Issue6
Pagination1195-201
Date Published1974 Dec
ISSN0019-9567
KeywordsAnimals, Antibodies, Bacterial, Cattle, Escherichia coli Infections, Fluorescent Antibody Technique, Goats, Hemagglutination Tests, Hemocyanin, Hemolysis, Histones, Immune Sera, Immunity, Maternally-Acquired, Immunization Schedule, Injections, Intravenous, Intestine, Small, Intestines, Klebsiella, Lethal Dose 50, Lipids, Male, Mercaptoethanol, Mice, Precipitin Tests, Rabbits, Salmonella, Salmonella Infections, Serum Albumin, Bovine, Swine
Abstract

The ability of antisera to lipid A, induced in rabbits by immunization with lipid A complexed to various carriers, to protect mice against gram-negative infection and to inhibit the fluid loss caused by an enteropathogenic strain of Escherichia coli in the piglet ligated gut was investigated. No significant protection was obtained in either case, although passive hemolysis and quantitative precipitation tests showed the presence of antilipid A antibodies in the sera. Fluorescent antibody studies suggest that the lipid A is in a cryptic position on the surface of smooth strains of gram-negative bacteria.
Alternate JournalInfect. Immun.
PubMed ID4611919
PubMed Central IDPMC423086