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Prevalence of human herpesvirus-8 salivary shedding in HIV increases with CD4 count.
Title | Prevalence of human herpesvirus-8 salivary shedding in HIV increases with CD4 count. |
Publication Type | Journal Article |
Year of Publication | 2004 |
Authors | Gandhi, M, Koelle, DM, Ameli, N, Bacchetti, P, Greenspan, JS, Navazesh, M, Anastos, K, Greenblatt, RM |
Journal | J Dent Res |
Volume | 83 |
Issue | 8 |
Pagination | 639-43 |
Date Published | 2004 Aug |
ISSN | 0022-0345 |
Keywords | Anti-HIV Agents, Antiretroviral Therapy, Highly Active, Body Fluids, CD4 Lymphocyte Count, Disease Progression, DNA, Viral, Female, Herpesviridae Infections, Herpesvirus 8, Human, HIV Infections, Humans, Predictive Value of Tests, Saliva, Sarcoma, Kaposi, Severity of Illness Index, Virus Shedding |
Abstract | Human herpesvirus-8 (HHV-8) is the etiologic agent of Kaposi's sarcoma (KS), which occurs in epidemic form in human immunodeficiency virus(HIV)-infected individuals. Saliva is the only mucosal fluid in which infectious HHV-8 has been identified, although factors associated with HHV-8 salivary shedding remain unclear. Our study performed PCR analysis for HHV-8 DNA in saliva (and other body fluids) in 66 HIV- and HHV-8-co-infected women without KS so that we could examine predictors for HHV-8 DNA detection. CD4 count was the most significant predictor of HHV-8 salivary shedding, with increased prevalence of HHV-8 salivary DNA at higher CD4 counts. The odds of salivary HHV8 shedding at CD4 counts > = 350 cells/microL was 63 times the odds of shedding at CD4 < 350 (95%CI, 1.3-3078), with an increase in effect size when the analysis was restricted to those with a CD4 nadir > 200. Analysis of these data suggests an increased potential for HHV-8 transmission early in HIV infection, with implications for HHV-8 prevention. |
Alternate Journal | J. Dent. Res. |
PubMed ID | 15271974 |