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Periodontitis vaccine decreases local prostaglandin E2 levels in a primate model.

TitlePeriodontitis vaccine decreases local prostaglandin E2 levels in a primate model.
Publication TypeJournal Article
Year of Publication2004
AuthorsRoberts, FA, Houston, LS, Lukehart, SA, Mancl, LA, G Persson, R, Page, RC
JournalInfect Immun
Volume72
Issue2
Pagination1166-8
Date Published2004 Feb
ISSN0019-9567
KeywordsAnimals, Bacterial Vaccines, Dinoprostone, Disease Models, Animal, Gingival Crevicular Fluid, Immunization, Interleukin-1, Macaca fascicularis, Periodontitis, Porphyromonas gingivalis, Tumor Necrosis Factor-alpha
Abstract

Interleukin-1beta, tumor necrosis factor alpha, prostaglandin E2 (PGE2), and Porphyromonas gingivalis-specific immunoglobulin G levels in gingival crevicular fluid were measured in primates immunized with a P. gingivalis vaccine followed by ligature-induced periodontitis. Only PGE2 levels were dramatically suppressed (P < 0.0001) in immunized animals versus controls. A significant correlation (P < 0.027) was also found between PGE2 levels and decreased bone loss scores. This study presents the first evidence of a potential mechanism involved in periodontitis vaccine-induced suppression of bone loss in a nonhuman primate model and offers insight into the role of PGE2 in periodontal destruction.
Alternate JournalInfect. Immun.
PubMed ID14742568
PubMed Central IDPMC321623
Grant ListDE-00431 / DE / NIDCR NIH HHS / United States
DE-08555 / DE / NIDCR NIH HHS / United States
DE-12939 / DE / NIDCR NIH HHS / United States