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Origins of CD4(+) effector and central memory T cells.
Title | Origins of CD4(+) effector and central memory T cells. |
Publication Type | Journal Article |
Year of Publication | 2011 |
Authors | Pepper, M, Jenkins, MK |
Journal | Nat Immunol |
Volume | 12 |
Issue | 6 |
Pagination | 467-71 |
Date Published | 2011 Jun |
ISSN | 1529-2916 |
Keywords | Animals, B-Lymphocytes, CD4-Positive T-Lymphocytes, Dendritic Cells, Humans, Immunologic Memory, Models, Immunological, T-Lymphocytes, Regulatory, Th1 Cells, Th17 Cells |
Abstract | Lineage-committed effector CD4(+) T cells are generated at the peak of the primary response and are followed by heterogeneous populations of central and effector memory cells. Here we review the evidence that T helper type 1 (T(H)1) effector cells survive the contraction phase of the primary response and become effector memory cells. We discuss the applicability of this idea to the T(H)2 cell, T(H)17 helper T cell, follicular helper T cell (T(FH) cell) and induced regulatory T cell lineages. We also discuss how central memory cells are formed, with an emphasis on the role of B cells in this process. |
Alternate Journal | Nat. Immunol. |
PubMed ID | 21739668 |