You are here

Home ยป Opsonization of Treponema pallidum is mediated by immunoglobulin G antibodies induced only by pathogenic treponemes.

Opsonization of Treponema pallidum is mediated by immunoglobulin G antibodies induced only by pathogenic treponemes.

TitleOpsonization of Treponema pallidum is mediated by immunoglobulin G antibodies induced only by pathogenic treponemes.
Publication TypeJournal Article
Year of Publication1993
AuthorsShaffer, JM, Baker-Zander, SA, Lukehart, SA
JournalInfect Immun
Volume61
Issue2
Pagination781-4
Date Published1993 Feb
ISSN0019-9567
KeywordsAnimals, Antibodies, Bacterial, Immune Sera, Immunoglobulin G, Phagocytosis, Rabbits, Treponema pallidum
Abstract

Rabbit antisera to Leptospira interrogans, Borrelia hermsii, and Treponema phagedenis biotype Reiter, reactive to shared spirochetal antigens, failed to enhance phagocytosis of Treponema pallidum by macrophages, while immunoglobulin G to Treponema pallidum subsp. pertenue and Treponema paraluiscuniculi promoted phagocytosis. Opsonic antibodies are directed to pathogen-restricted, not shared spirochetal, antigens.
Alternate JournalInfect. Immun.
PubMed ID8423106
PubMed Central IDPMC302795
Grant ListAI 18988 / AI / NIAID NIH HHS / United States