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Opposing signals from the Bcl6 transcription factor and the interleukin-2 receptor generate T helper 1 central and effector memory cells.
Title | Opposing signals from the Bcl6 transcription factor and the interleukin-2 receptor generate T helper 1 central and effector memory cells. |
Publication Type | Journal Article |
Year of Publication | 2011 |
Authors | Pepper, M, Pagán, AJ, Igyártó, BZ, Taylor, JJ, Jenkins, MK |
Journal | Immunity |
Volume | 35 |
Issue | 4 |
Pagination | 583-95 |
Date Published | 2011 Oct 28 |
ISSN | 1097-4180 |
Keywords | Animals, Cell Differentiation, DNA-Binding Proteins, Immunologic Memory, Inducible T-Cell Co-Stimulator Protein, Interleukin-2 Receptor alpha Subunit, Mice, Receptors, CXCR5, Receptors, Interleukin-2, Signal Transduction, Th1 Cells |
Abstract | Listeria monocytogenes infection generates T helper 1 (Th1) effector memory cells and CC chemokine receptor 7 (CCR7)(+) cells resembling central memory cells. We tracked endogenous L. monocytogenes-specific CD4(+) T cells to determine how these memory cells are formed. Two effector cell populations were already present several days after infection. One highly expressed the T-bet transcription factor and produced Th1 memory cells in an interleukin-2 (IL-2) receptor-dependent fashion. The other resided in the T cell areas, expressed CCR7 and CXC chemokine receptor 5 (CXCR5), and like follicular helper cells depended on the Bcl6 transcription factor and inducible costimulator ligand on B cells. The CCR7(+)CXCR5(+) effector cells produced similar memory cells that generated diverse effector cell populations in a secondary response. Thus, Th1 effector memory and follicular helper-like central memory cells are produced from early effector cell populations that diverge in response to signals from the IL-2 receptor, Bcl6, and B cells. |
DOI | 10.1016/j.immuni.2011.09.009 |
Alternate Journal | Immunity |
PubMed ID | 22018468 |
PubMed Central ID | PMC3208313 |
Grant List | R01 AI039614-16 / AI / NIAID NIH HHS / United States R01 AI066018-05 / AI / NIAID NIH HHS / United States R01-AI39614 / AI / NIAID NIH HHS / United States R01-AI66018 / AI / NIAID NIH HHS / United States R01-AR056632 / AR / NIAMS NIH HHS / United States R37 AI027998-23 / AI / NIAID NIH HHS / United States R37-AI27998 / AI / NIAID NIH HHS / United States T32-AI07313 / AI / NIAID NIH HHS / United States |