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Home ยป Multidrug-resistant genes are associated with an 86-kb island in Acinetobacter baumannii.

Multidrug-resistant genes are associated with an 86-kb island in Acinetobacter baumannii.

TitleMultidrug-resistant genes are associated with an 86-kb island in Acinetobacter baumannii.
Publication TypeJournal Article
Year of Publication2006
AuthorsRoberts, MC
JournalTrends Microbiol
Volume14
Issue9
Pagination375-8
Date Published2006 Sep
ISSN0966-842X
KeywordsAcinetobacter baumannii, Anti-Bacterial Agents, Drug Resistance, Multiple, Bacterial, Genes, Bacterial, Genome, Bacterial, Metals, Heavy, Microbial Sensitivity Tests
Abstract

A strain of multidrug-resistant Acinetobacter baumannii that caused a 26% mortality rate in a French epidemic was characterized and compared with an antibiotic-susceptible strain of A. baumannii. The multiresistant strain carries many of its antibiotic-resistance genes on an 86-kb region, whereas the susceptible strain lacks these genes in a homologous region. Characterization of this multidrug-resistant A. baumannii strain highlights the limited options for current therapy and raises concerns for future treatment options in an era in which few novel antibiotics are being developed.
DOI10.1016/j.tim.2006.07.005
Alternate JournalTrends Microbiol.
PubMed ID16876998
Grant ListN01DE72623 / DE / NIDCR NIH HHS / United States
P50DE14254 / DE / NIDCR NIH HHS / United States
U01DE1189 / DE / NIDCR NIH HHS / United States