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Lesions of primary and secondary syphilis contain activated cytolytic T cells.
| Title | Lesions of primary and secondary syphilis contain activated cytolytic T cells. |
| Publication Type | Journal Article |
| Year of Publication | 1996 |
| Authors | Van Voorhis, WC, Barrett, LK, Nasio, JM, Plummer, FA, Lukehart, SA |
| Journal | Infect Immun |
| Volume | 64 |
| Issue | 3 |
| Pagination | 1048-50 |
| Date Published | 1996 Mar |
| ISSN | 0019-9567 |
| Keywords | Base Sequence, Granzymes, Humans, Lymphocyte Activation, Molecular Sequence Data, RNA, Messenger, Serine Endopeptidases, Syphilis, T-Lymphocytes, Cytotoxic, Treponema pallidum |
| Abstract | This study demonstrates that CD8+ cytotoxic lymphocytes (CTL) are found in both primary and secondary syphilis lesions. CD8+ T cells were detected by immunohistology, and mRNAs for granzyme B and perforin were detected by reverse transcription and PCR, suggesting that CD8+ cytotoxic lymphocytes are activated. |
| Alternate Journal | Infect. Immun. |
| PubMed ID | 8641758 |
