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Home ยป Isocitrate lyase (AceA) is required for Salmonella persistence but not for acute lethal infection in mice.

Isocitrate lyase (AceA) is required for Salmonella persistence but not for acute lethal infection in mice.

TitleIsocitrate lyase (AceA) is required for Salmonella persistence but not for acute lethal infection in mice.
Publication TypeJournal Article
Year of Publication2005
AuthorsFang, FC, Libby, SJ, Castor, ME, Fung, AM
JournalInfect Immun
Volume73
Issue4
Pagination2547-9
Date Published2005 Apr
ISSN0019-9567
KeywordsAcute Disease, Animals, Female, Isocitrate Lyase, Mice, Mice, Inbred C3H, Salmonella Infections, Animal, Salmonella typhimurium
Abstract

Isocitrate lyase is required for fatty acid utilization via the glyoxylate shunt. Although isocitrate lyase is essential for Salmonella persistence during chronic infection, it is dispensable for acute lethal infection in mice. Substrate availability in the phagosome appears to evolve over time, with increasing fatty acid dependence during chronic infection.
DOI10.1128/IAI.73.4.2547-2549.2005
Alternate JournalInfect. Immun.
PubMed ID15784602
PubMed Central IDPMC1087437
Grant ListAI39557 / AI / NIAID NIH HHS / United States
AI44486 / AI / NIAID NIH HHS / United States