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Iron and citrate export by a major facilitator superfamily pump regulates metabolism and stress resistance in Salmonella Typhimurium.
Title | Iron and citrate export by a major facilitator superfamily pump regulates metabolism and stress resistance in Salmonella Typhimurium. |
Publication Type | Journal Article |
Year of Publication | 2013 |
Authors | Frawley, ER, Crouch, M-LV, Bingham-Ramos, LK, Robbins, HF, Wang, W, Wright, GD, Fang, FC |
Journal | Proc Natl Acad Sci U S A |
Volume | 110 |
Issue | 29 |
Pagination | 12054-9 |
Date Published | 2013 Jul 16 |
ISSN | 1091-6490 |
Keywords | Bacterial Proteins, Citric Acid, Computational Biology, DNA Transposable Elements, Drug Resistance, Bacterial, Energy Metabolism, Iron Compounds, Membrane Transport Proteins, Microscopy, Interference, Nitric Oxide, Oxidative Stress, Salmonella typhimurium, Streptonigrin |
Abstract | The efficacy of antibiotics and host defenses has been linked to the metabolic and redox states of bacteria. In this study we report that a stress-induced export pump belonging to the major facilitator superfamily effluxes citrate and iron from the enteric pathogen Salmonella Typhimurium to arrest growth and ameliorate the effects of antibiotics, hydrogen peroxide, and nitric oxide. The transporter, formerly known as MdtD, is now designated IceT (iron citrate efflux transporter). Iron efflux via an iron-chelating tricarboxylic acid cycle intermediate provides a direct link between aerobic metabolism and bacterial stress responses, representing a unique mechanism of resistance to host defenses and antimicrobial agents of diverse classes. |
DOI | 10.1073/pnas.1218274110 |
Alternate Journal | Proc. Natl. Acad. Sci. U.S.A. |
PubMed ID | 23821749 |
PubMed Central ID | PMC3718157 |
Grant List | AI39557 / AI / NIAID NIH HHS / United States AI44486 / AI / NIAID NIH HHS / United States AI54052 / AI / NIAID NIH HHS / United States AI77629 / AI / NIAID NIH HHS / United States R01 AI044486 / AI / NIAID NIH HHS / United States |