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Home ยป Interstrain conservation of babesial RAP-1 surface-exposed B-cell epitopes despite rap-1 genomic polymorphism.

Interstrain conservation of babesial RAP-1 surface-exposed B-cell epitopes despite rap-1 genomic polymorphism.

TitleInterstrain conservation of babesial RAP-1 surface-exposed B-cell epitopes despite rap-1 genomic polymorphism.
Publication TypeJournal Article
Year of Publication1994
AuthorsSuarez, CE, McElwain, TF, Echaide, I, S de Echaide, T, Palmer, GH
JournalInfect Immun
Volume62
Issue8
Pagination3576-9
Date Published1994 Aug
ISSN0019-9567
KeywordsAnimals, Antigens, Protozoan, B-Lymphocytes, Babesia, Epitopes, Genes, Protozoan, Humans, Open Reading Frames, Polymorphism, Genetic, Protozoan Proteins
Abstract

Members of the babesial rhoptry-associated protein 1 (RAP-1) family express surface-exposed B-cell epitopes and are candidate antigens for vaccine development. The relationship between rap-1 genomic polymorphism and surface-exposed B-cell epitope expression was analyzed by comparison of biological clones of Mexico strain Babesia bigemina and Babesia bovis with strains isolated in Argentina. Despite genomic polymorphism between strains, including sequences located within the open reading frame, defined RAP-1 B-cell surface epitopes and RAP-1 molecular size were conserved in both B. bovis and B. bigemina.
Alternate JournalInfect. Immun.
PubMed ID7518810
PubMed Central IDPMC302997