You are here

Home ยป Insights into tuberculosis from the zebrafish model.

Insights into tuberculosis from the zebrafish model.

TitleInsights into tuberculosis from the zebrafish model.
Publication TypeJournal Article
Year of Publication2012
AuthorsBerg, RD, Ramakrishnan, L
JournalTrends Mol Med
Volume18
Issue12
Pagination689-90
Date Published2012 Dec
ISSN1471-499X
KeywordsAnimals, Disease Models, Animal, Granuloma, Mycobacterium marinum, Tuberculosis, Zebrafish
Abstract

Mycobacterium tuberculosis (MTB) continues to plague humanity because of significant gaps in our understanding of MTB infection, including the nature of a protective versus pathological host response, why antimicrobial cure is so difficult, and the ineffectiveness of vaccination. The development of a zebrafish model, utilizing infection with the natural fish pathogen Mycobacterium marinum (Mm), has yielded important insights into tuberculosis with immediate clinical applications.
DOI10.1016/j.molmed.2012.10.002
Alternate JournalTrends Mol Med
PubMed ID23084762
Grant ListDP1 MH099901 / MH / NIMH NIH HHS / United States
F30 HL110455 / HL / NHLBI NIH HHS / United States
R37 AI054503 / AI / NIAID NIH HHS / United States