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Insights into early mycobacterial pathogenesis from the zebrafish.
Title | Insights into early mycobacterial pathogenesis from the zebrafish. |
Publication Type | Journal Article |
Year of Publication | 2008 |
Authors | Lesley, R, Ramakrishnan, L |
Journal | Curr Opin Microbiol |
Volume | 11 |
Issue | 3 |
Pagination | 277-83 |
Date Published | 2008 Jun |
ISSN | 1369-5274 |
Keywords | Animals, Disease Models, Animal, Host-Pathogen Interactions, Humans, Macrophages, Mycobacterium, Mycobacterium Infections, Mycobacterium tuberculosis, Tuberculosis, Zebrafish |
Abstract | Here we discuss the application of the zebrafish as a relatively new model host for the study of mycobacterial pathogenesis. Recent advances in our understanding of host-mycobacteria interactions from the zebrafish include insights into the role of the innate immune system in both controlling and facilitating infection. Analysis in the zebrafish has revealed that innate macrophages restrict initial bacterial growth, but also convey infecting bacteria into the granuloma, which serves as a place for bacterial growth and spread. Bacterial virulence determinants interact with these processes at different steps in pathogenesis, which can be dissected in these living see-through hosts. As these studies uncover new facets of the bacteria-host interactions in tuberculosis they raise even more questions for future investigation. |
DOI | 10.1016/j.mib.2008.05.013 |
Alternate Journal | Curr. Opin. Microbiol. |
PubMed ID | 18571973 |
PubMed Central ID | PMC3071758 |
Grant List | NIH R01AI 36396 / AI / NIAID NIH HHS / United States NIH R01AI 54503 / AI / NIAID NIH HHS / United States R01 AI054503-05 / AI / NIAID NIH HHS / United States / / Wellcome Trust / United Kingdom |