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Innate immunity in the lungs.
Title | Innate immunity in the lungs. |
Publication Type | Journal Article |
Year of Publication | 2005 |
Authors | Martin, TR, Frevert, CW |
Journal | Proc Am Thorac Soc |
Volume | 2 |
Issue | 5 |
Pagination | 403-11 |
Date Published | 2005 |
ISSN | 1546-3222 |
Keywords | Animals, Humans, Immune System, Immunity, Innate, Lung, Lung Diseases, Models, Immunological, Rabbits, Sensitivity and Specificity, Signal Transduction, Toll-Like Receptors |
Abstract | Innate immunity is a primordial system that has a primary role in lung antimicrobial defenses. Recent advances in understanding the recognition systems by which cells of the innate immune system recognize and respond to microbial products have revolutionized the understanding of host defenses in the lungs and other tissues. The innate immune system includes lung leukocytes and also epithelial cells lining the alveolar surface and the conducting airways. The innate immune system drives adaptive immunity in the lungs and has important interactions with other systems, including apoptosis pathways and signaling pathways induced by mechanical stretch. Human diversity in innate immune responses could explain some of the variability seen in the responses of patients to bacterial, fungal, and viral infections in the lungs. New strategies to modify innate immune responses could be useful in limiting the adverse consequences of some inflammatory reactions in the lungs. |
DOI | 10.1513/pats.200508-090JS |
Alternate Journal | Proc Am Thorac Soc |
PubMed ID | 16322590 |
PubMed Central ID | PMC2713330 |
Grant List | GM37696 / GM / NIGMS NIH HHS / United States HL65892 / HL / NHLBI NIH HHS / United States HL73996 / HL / NHLBI NIH HHS / United States |