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Home ยป Human immunodeficiency virus types 1 and 2 exhibit comparable sensitivities to Zidovudine and other nucleoside analog inhibitors in vitro.

Human immunodeficiency virus types 1 and 2 exhibit comparable sensitivities to Zidovudine and other nucleoside analog inhibitors in vitro.

TitleHuman immunodeficiency virus types 1 and 2 exhibit comparable sensitivities to Zidovudine and other nucleoside analog inhibitors in vitro.
Publication TypeJournal Article
Year of Publication2008
AuthorsSmith, RA, Gottlieb, GS, Anderson, DJ, Pyrak, CL, Preston, BD
JournalAntimicrob Agents Chemother
Volume52
Issue1
Pagination329-32
Date Published2008 Jan
ISSN0066-4804
KeywordsAnti-HIV Agents, HeLa Cells, HIV-1, HIV-2, Humans, Microbial Sensitivity Tests, Reverse Transcriptase Inhibitors, Zidovudine
Abstract

Using an indicator cell assay that directly quantifies viral replication, we show that human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2, respectively) exhibit similar sensitivities to 3'-azido-3'-deoxythymidine (zidovudine) as well as other nucleoside analog inhibitors of reverse transcriptase. These data support the use of nucleoside analogs for antiviral therapy of HIV-2 infection.
DOI10.1128/AAC.01004-07
Alternate JournalAntimicrob. Agents Chemother.
PubMed ID17967913