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Human DBI (endozepine): relationship to a homologous membrane associated protein (MA-DBI).
Title | Human DBI (endozepine): relationship to a homologous membrane associated protein (MA-DBI). |
Publication Type | Journal Article |
Year of Publication | 1991 |
Authors | Todaro, GJ, Rose, TM, Shoyab, M |
Journal | Neuropharmacology |
Volume | 30 |
Issue | 12B |
Pagination | 1373-80 |
Date Published | 1991 Dec |
ISSN | 0028-3908 |
Keywords | Amino Acid Sequence, Animals, Base Sequence, Cattle, Diazepam Binding Inhibitor, Humans, Membrane Proteins, Models, Structural, Molecular Sequence Data, Neuropeptides, Protein Conformation, Sequence Homology, Nucleic Acid |
Abstract | Human endozepine, an 86 amino acid polypeptide, was originally isolated from human brain tissue as a putative ligand of the benzodiazepine receptor. Complete amino acid sequencing of the human and bovine proteins revealed significant homology with the partial sequence of diazepam binding inhibitor (DBI), a protein from rat brain. Both endozepine and DBI have been shown to elicit behavioral effects, suggesting that they function as pharmacologically-active ligands of the GABA (gamma-aminobutyric acid) receptor complex. Subsequent cDNA cloning of human and bovine endozepine, rat DBI and human DBI has shown that these proteins are encoded by the same gene. A related cDNA, encoding a transmembrane protein of 533 amino acids with a domain homologous to DBI, has also been cloned from bovine brain. |
Alternate Journal | Neuropharmacology |
PubMed ID | 1780036 |