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Homeostatic regulation of Salmonella-induced mucosal inflammation and injury by IL-23.
| Title | Homeostatic regulation of Salmonella-induced mucosal inflammation and injury by IL-23. |
| Publication Type | Journal Article |
| Year of Publication | 2012 |
| Authors | Awoniyi, M, Miller, SI, Wilson, CB, Hajjar, AM, Smith, KD |
| Journal | PLoS One |
| Volume | 7 |
| Issue | 5 |
| Pagination | e37311 |
| Date Published | 2012 |
| ISSN | 1932-6203 |
| Keywords | Analysis of Variance, Animals, Female, Flow Cytometry, Gene Expression Regulation, Homeostasis, Immunohistochemistry, Interferon-gamma, Interleukin-12, Interleukin-23 Subunit p19, Interleukins, Intestinal Mucosa, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Real-Time Polymerase Chain Reaction, Receptors, Interleukin, Salmonella Infections, Salmonella typhimurium |
| Abstract | IL-12 and IL-23 regulate innate and adaptive immunity to microbial pathogens through influencing the expression of IFN-γ, IL-17, and IL-22. Herein we define the roles of IL-12 and IL-23 in regulating host resistance and intestinal inflammation during acute Salmonella infection. We find that IL-23 alone is dispensable for protection against systemic spread of bacteria, but synergizes with IL-12 for optimal protection. IL-12 promotes the production of IFN-γ by NK cells, which is required for resistance against Salmonella and also for induction of intestinal inflammation and epithelial injury. In contrast, IL-23 controls the severity of inflammation by inhibiting IL-12A expression, reducing IFN-γ and preventing excessive mucosal injury. Our studies demonstrate that IL-23 is a homeostatic regulator of IL-12-dependent, IFN-γ-mediated intestinal inflammation. |
| DOI | 10.1371/journal.pone.0037311 |
| Alternate Journal | PLoS ONE |
| PubMed ID | 22624013 |
