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High prevalence of multidrug-resistant Streptococcus pneumoniae among children in a rural Kentucky community.
Title | High prevalence of multidrug-resistant Streptococcus pneumoniae among children in a rural Kentucky community. |
Publication Type | Journal Article |
Year of Publication | 1995 |
Authors | Duchin, JS, Breiman, RF, Diamond, A, Lipman, HB, Block, SL, Hedrick, JA, Finger, R, Elliott, JA |
Journal | Pediatr Infect Dis J |
Volume | 14 |
Issue | 9 |
Pagination | 745-50 |
Date Published | 1995 Sep |
ISSN | 0891-3668 |
Keywords | Carrier State, Child, Child Day Care Centers, Child, Preschool, Drug Resistance, Microbial, Drug Resistance, Multiple, Humans, Infant, Kentucky, Logistic Models, Microbial Sensitivity Tests, Nasopharynx, Otitis Media with Effusion, Pneumococcal Infections, Prevalence, Rural Population, Streptococcus pneumoniae |
Abstract | In 1992 drug-resistant Streptococcus pneumoniae was cultured with increasing frequency from aspirates of middle ear fluid from children with acute otitis media in a rural Kentucky community. To determine the prevalence of carriage of drug-resistant S. pneumoniae in the community, we obtained nasopharyngeal swabs from 158 (70%) of 227 children attending a child daycare center and from 82 children attending the county health center. S. pneumoniae was isolated from 126 children. Among 123 isolates tested 65 (53%) were penicillin-resistant, including 41 (33%) strains that were highly resistant; 61 (50%) were multidrug-resistant. Serotypes 19F, 6B, 23F and 6A comprised 89% of the penicillin-resistant isolates. Detection of a variety of serotypes and drug resistance patterns among nasopharyngeal isolates of S. pneumoniae suggests that multidrug-resistant pneumococcal strains are endemic in this community. Surveillance for drug-resistant pneumococci with the use of respiratory secretions obtained by nasopharyngeal swab may provide useful information on the prevalence of drug-resistant strains causing invasive disease and otitis media. Such information could be used to guide empiric therapy of pneumococcal infections. |
Alternate Journal | Pediatr. Infect. Dis. J. |
PubMed ID | 8559622 |