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High frequency of CD8+ cytotoxic T-lymphocyte precursors specific for herpes simplex viruses in persons with genital herpes.
Title | High frequency of CD8+ cytotoxic T-lymphocyte precursors specific for herpes simplex viruses in persons with genital herpes. |
Publication Type | Journal Article |
Year of Publication | 1996 |
Authors | Posavad, CM, Koelle, DM, Corey, L |
Journal | J Virol |
Volume | 70 |
Issue | 11 |
Pagination | 8165-8 |
Date Published | 1996 Nov |
ISSN | 0022-538X |
Keywords | Herpes Genitalis, Herpes Simplex, Herpesvirus 1, Human, Herpesvirus 2, Human, Histocompatibility Antigens Class I, Humans, T-Lymphocytes, Cytotoxic, Tumor Cells, Cultured |
Abstract | Herpes simplex virus (HSV)-specific CD8+ cytotoxic T lymphocytes (CTL) have rarely been detected in humans, presumably because of virus-induced mechanisms that downregulate major histocompatibility complex class I expression. We have developed a method that has allowed us to consistently demonstrate HSV-specific CD8+ precursor CTL (pCTL) from HSV type 1- and 2-seropositive persons. Major histocompatibility complex-restricted HSV-specific CD8+ pCTL were found in 10 consecutively tested HSV type 1- and 2-seropositive subjects at frequencies ranging from 1 in 21,000 to 1 in 300 (median, 1 in 6,000) versus a pCTL frequency of 1 in 100,000 in HSV-seronegative donors. These results suggest that CD8+ CTL are important effector cells in resolving HSV lesions. |
Alternate Journal | J. Virol. |
PubMed ID | 8892947 |