You are here

Home ยป Glucose 6-phosphate dehydrogenase is required for Salmonella typhimurium virulence and resistance to reactive oxygen and nitrogen intermediates.

Glucose 6-phosphate dehydrogenase is required for Salmonella typhimurium virulence and resistance to reactive oxygen and nitrogen intermediates.

TitleGlucose 6-phosphate dehydrogenase is required for Salmonella typhimurium virulence and resistance to reactive oxygen and nitrogen intermediates.
Publication TypeJournal Article
Year of Publication1999
AuthorsLundberg, BE, Wolf, RE, Dinauer, MC, Xu, Y, Fang, FC
JournalInfect Immun
Volume67
Issue1
Pagination436-8
Date Published1999 Jan
ISSN0019-9567
KeywordsAnimals, Antioxidants, Female, Glucosephosphate Dehydrogenase, Glutathione, Hydrogen Peroxide, Mice, Mice, Inbred C57BL, Mice, Knockout, Nitrogen, Nitroso Compounds, Phagocytes, Reactive Oxygen Species, S-Nitrosoglutathione, Salmonella typhimurium, Virulence
Abstract

Salmonella typhimurium zwf mutants lacking glucose 6-phosphate dehydrogenase (G6PD) activity have increased susceptibility to reactive oxygen and nitrogen intermediates as well as attenuated virulence in mice. Abrogation of the phagocyte respiratory burst oxidase during experimental infection with zwf mutant Salmonella causes a prompt restoration of virulence, while inhibition of inducible nitric oxide synthase results in delayed lethality. These observations suggest that G6PD-dependent bacterial antioxidant defenses play an important pathogenic role during early salmonellosis and additionally may help to antagonize NO-dependent antimicrobial mechanisms later in the course of infection.
Alternate JournalInfect. Immun.
PubMed ID9864251
PubMed Central IDPMC96332
Grant ListAI39557 / AI / NIAID NIH HHS / United States