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Emerging therapeutic strategies to prevent infection-related microvascular endothelial activation and dysfunction.
Title | Emerging therapeutic strategies to prevent infection-related microvascular endothelial activation and dysfunction. |
Publication Type | Journal Article |
Year of Publication | 2013 |
Authors | Darwish, I, W Liles, C |
Journal | Virulence |
Volume | 4 |
Issue | 6 |
Pagination | 572-82 |
Date Published | 2013 Aug 15 |
ISSN | 2150-5608 |
Abstract | Recent evidence suggests that loss of endothelial barrier function and resulting microvascular leak play important mechanistic roles in the pathogenesis of infection-related end-organ dysfunction and failure. Several distinct therapeutic strategies, designed to prevent or limit infection-related microvascular endothelial activation and permeability, thereby mitigating end-organ injury/dysfunction, have recently been investigated in pre-clinical models. In this review, these potential therapeutic strategies, namely, VEGFR2/Src antagonists, sphingosine-1-phosphate agonists, fibrinopeptide Bβ 15-42, slit2N, secinH3, angiopoietin-1/tie-2 agonists, angiopoietin-2 antagonists, statins, atrial natriuretic peptide, and mesenchymal stromal (stem) cells, are discussed in terms of their translational potential for the management of clinical infectious diseases. |
DOI | 10.4161/viru.25740 |
Alternate Journal | Virulence |
PubMed ID | 23863603 |